Molecular structure of AC-265347, CAS Number: 1253901-26-6
AC-265347 (CAS 1253901-26-6)
See product citations (1)
Alternate Names:
1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol
Application:
AC-265347 is a CaSR (calcium-sensing receptor) activator and allosteric agonist
CAS Number:
1253901-26-6
Purity:
≥98%
Molecular Weight:
283.39
Molecular Formula:
C17H17NOS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AC-265347 is a CaSR (calcium-sensing receptor) activator and allosteric agonist. AC-265347 activates CaSR signaling in cellular proliferation and phosphatidyl inositol (PI) hydrolysis assays.
AC-265347 (CAS 1253901-26-6) References
- Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. | Ma, JN., et al. 2011. J Pharmacol Exp Ther. 337: 275-84. PMID: 21239511
- Intercepting the Breslow intermediate via Claisen rearrangement: synthesis of complex tertiary alcohols without organometallic reagents. | Alwarsh, S., et al. 2013. Org Lett. 15: 3-5. PMID: 23214715
- Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. | Cook, AE., et al. 2015. Br J Pharmacol. 172: 185-200. PMID: 25220431
- Concise Access to 2-Aroylbenzothiazoles by Redox Condensation Reaction between o-Halonitrobenzenes, Acetophenones, and Elemental Sulfur. | Nguyen, TB., et al. 2015. Org Lett. 17: 2562-5. PMID: 25929738
- Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. | Leach, K., et al. 2016. Cell Res. 26: 574-92. PMID: 27002221
- Recent advances in understanding the extracellular calcium-sensing receptor. | Colella, M., et al. 2016. F1000Res. 5: PMID: 27803801
- Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity. | Diepenhorst, NA., et al. 2018. Br J Pharmacol. 175: 4095-4108. PMID: 29714810
- Aromatherapy: Activating olfactory calcium-sensing receptors impairs renal hemodynamics via sympathetic nerve-mediated vasoconstriction. | Lee, SP., et al. 2019. Acta Physiol (Oxf). 225: e13157. PMID: 29939497
- Activation of calcium-sensing receptor by allosteric agonists cinacalcet and AC-265347 abolishes the 1,25(OH)2D3-induced Ca2+ transport: Evidence that explains how the intestine prevents excessive Ca2+ absorption. | Wongdee, K., et al. 2018. Arch Biochem Biophys. 657: 15-22. PMID: 30217510
- Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine. | Barahona, MJ., et al. 2019. Front Physiol. 10: 439. PMID: 31130866
- Development of AC265347-Inspired Calcium-Sensing Receptor Ago-Positive Allosteric Modulators. | Dinh, LV., et al. 2021. ChemMedChem. 16: 3451-3462. PMID: 34216111
- Urothelial Calcium-Sensing Receptor Modulates Micturition Function via Mediating Detrusor Activity and Ameliorates Bladder Hyperactivity in Rats. | Wu, WY., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34681183
- AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia. | Gonçalves-Alves, E., et al. 2022. Int J Mol Sci. 23: PMID: 35457141
Activator of:
CaSR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC-265347, 5 mg | sc-364395 | 5 mg | $87.00 | |||
AC-265347, 25 mg | sc-364395A | 25 mg | $370.00 |