R 568 hydrochloride CAS: 177172-49-5
R 568 hydrochloride is an activator and allosteric agonist of the CaSR.

R 568 hydrochloride (CAS 177172-49-5)

R 568 hydrochloride | CAS 177172-49-5 is rated 5.0 out of 5 by 1.
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Alternate Names: 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride
Application: R 568 hydrochloride is an activator and allosteric agonist of the CaSR
CAS Number: 177172-49-5
Purity: ≥97%
Molecular Weight: 340.29
Molecular Formula: C18H22ClNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

R 568 hydrochloride is an activator and allosteric agonist of the CaSR (calcium-sensing receptor) via positive allosteric modulation. R 568 hydrochloride exhibits calcimimetic activity. R 568 hydrochloride has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). R 568 hydrochloride exerts a suppressive effect on parathyroid (PT) hormone secretion.


References

1. Wada, M., et al., 1997. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. The Journal of clinical investigation. 100(12): 2977-83. PMID: 9399943
2. Fox, J., et al., 1999. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. The Journal of pharmacology and experimental therapeutics. 290(2): 473-9. PMID: 10411552
3. Lu, Jenny Ying Lin., et al., 2009. Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor. The Journal of pharmacology and experimental therapeutics. 331(3): 775-86. PMID: 19759318

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
416.3° C at 760 mmHg (Predicted)
Optical Activity :
α20/D +42°, c = 1 in chloroform
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
158796
MDL Number :
MFCD16038895
SMILES :
C[[email protected]](C1=CC(=CC=C1)OC)NCCCC2=CC=CC=C2Cl.Cl

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Certificate of Analysis

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R 568 hydrochloride (CAS 177172-49-5)  Product Citations

See how others have used R 568 hydrochloride (CAS 177172-49-5). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25922231  Zhao, M. et al. 2015. Journal of pharmacological sciences. 127: 481-8.

PMID: # 32705187  Mol Med Rep. 2021-2031.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Lu et al Lu et al. (PubMed ID 19759318) used the calcimimetic, R-568, to transfect human embryonic kidney and Chines hamster ovary cells. -SCBT Publication Review
Date published: 2015-02-16
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