Molecular structure of R 568 hydrochloride, CAS Number: 177172-49-5
R 568 hydrochloride (CAS 177172-49-5)
See product citations (4)
Alternate Names:
R 568 hydrochloride is also known as Tecalcet Hydrochloride.
Application:
R 568 hydrochloride is an activator and allosteric agonist of the calcium-sensing receptor via positive allosteric modulation.
CAS Number:
177172-49-5
Purity:
≥97%
Molecular Weight:
340.29
Molecular Formula:
C18H22ClNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
R 568 hydrochloride is an activator and allosteric agonist of the CaSR (calcium-sensing receptor) via positive allosteric modulation. R 568 hydrochloride exhibits calcimimetic activity. R 568 hydrochloride has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). R 568 hydrochloride exerts a suppressive effect on parathyroid (PT) hormone secretion. R 568 hydrochloride, a white crystalline powder, readily dissolves in water and ethanol. As a calcium channel blocker, it hinders the entry of calcium into cells. Consequently, intracellular calcium levels decrease, leading to diverse effects on cell function. One notable impact is the inhibition of neurotransmitter release, including glutamate, which ultimately lowers neuron excitability.
R 568 hydrochloride (CAS 177172-49-5) References
- NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. | Fox, J., et al. 1999. J Pharmacol Exp Ther. 290: 473-9. PMID: 10411552
- Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor. | Lu, JY., et al. 2009. J Pharmacol Exp Ther. 331: 775-86. PMID: 19759318
- Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. | Engelstoft, MS., et al. 2013. Mol Metab. 2: 376-92. PMID: 24327954
- Acetylcholine protects mesenteric arteries against hypoxia/reoxygenation injury via inhibiting calcium-sensing receptor. | Zhao, M., et al. 2015. J Pharmacol Sci. 127: 481-8. PMID: 25922231
- Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells. | Egerod, KL., et al. 2015. Endocrinology. 156: 3909-23. PMID: 26181106
- A novel bioluminescence-based method to investigate uptake of bile acids in living cells. | Ticho, AL., et al. 2018. Am J Physiol Gastrointest Liver Physiol. 315: G529-G537. PMID: 29927324
- Calcimimetic R-568 vasodilatory effect on mesenteric vascular beds from normotensive (WKY) and spontaneously hypertensive (SHR) rats. Potential involvement of vascular smooth muscle cells (vSMCs). | Di Pietro, N., et al. 2018. PLoS One. 13: e0202354. PMID: 30092054
- Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling. | Markworth, R., et al. 2019. J Neurosci. 39: 5842-5860. PMID: 31123102
- The calcium-sensing receptor: A novel target for treatment and prophylaxis of neratinib-induced diarrhea. | Lysyy, T., et al. 2019. Pharmacol Res Perspect. 7: e00521. PMID: 31523434
- The calcimimetic R-568 attenuates subarachnoid hemorrhage-induced vasospasm through PI3K/Akt/eNOS signaling pathway in the rat model. | Güleç, İ., et al. 2021. Brain Res. 1765: 147508. PMID: 33930376
- Calcium-sensing receptor (CaSR) agonist R568 inhibits small intestinal motility of mice through neural and non-neural mechanisms. | Guo, Y., et al. 2021. Food Funct. 12: 11926-11937. PMID: 34739536
- The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. | Wada, M., et al. 1997. J Clin Invest. 100: 2977-83. PMID: 9399943
- Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568. | Lalonde, RL., et al. 1999. Clin Pharmacol Ther. 65: 40-9. PMID: 9951429
Inhibitor of:
CaSR, and resistin-like α.Activator of:
9030617O03Rik, and CaSR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R 568 hydrochloride, 10 mg | sc-361302 | 10 mg | $214.00 | |||
R 568 hydrochloride, 50 mg | sc-361302A | 50 mg | $877.00 |