R 568 hydrochloride is an activator and allosteric agonist of the CaSR (calcium-sensing receptor) via positive allosteric modulation. R 568 hydrochloride exhibits calcimimetic activity. R 568 hydrochloride has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). R 568 hydrochloride exerts a suppressive effect on parathyroid (PT) hormone secretion.
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2. Fox, J., et al., 1999. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. The Journal of pharmacology and experimental therapeutics. 290(2): 473-9. PMID: 10411552
3. Lu, Jenny Ying Lin., et al., 2009. Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor. The Journal of pharmacology and experimental therapeutics. 331(3): 775-86. PMID: 19759318
See how others have used R 568 hydrochloride (CAS 177172-49-5). Click on the entry to view the PubMed entry .
PMID: # 25922231 Zhao, M. et al. 2015. Journal of pharmacological sciences. 127: 481-8.
PMID: # 32705187 Mol Med Rep. 2021-2031.
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