casein kinase I epsilon Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $99.00 | 6 | |
D4476 is a specific inhibitor of Casein Kinase Iε. It directly binds to the catalytic domain of Casein Kinase Iε, disrupting its kinase activity and preventing phosphorylation of substrate proteins. This direct inhibition hampers Casein Kinase Iε-mediated signaling cascades and cellular processes that depend on its enzymatic activity, offering a targeted approach for modulating its function. | ||||||
CR8, (R)-Isomer | 294646-77-8 | sc-311306 | 5 mg | $174.00 | ||
CR8, the (R)-Isomer, acts as a selective modulator of casein kinase I epsilon, showcasing a unique affinity for specific phosphorylation sites. Its interaction with the enzyme alters conformational dynamics, promoting a shift in substrate specificity. This compound exhibits distinctive reaction kinetics, influencing the rate of phosphorylation and subsequent signaling pathways. By engaging in unique molecular interactions, CR8 provides insights into the regulatory mechanisms governing cellular functions. | ||||||
IC261 | 186611-52-9 | sc-3561 | 5 mg | $140.00 | 11 | |
IC261 is a potent and selective inhibitor of Casein Kinase Iε. By binding to the ATP-binding pocket of the kinase, IC261 interferes with the enzymatic activity, leading to the inhibition of Casein Kinase Iε-mediated phosphorylation events. This direct inhibition disrupts downstream signaling pathways regulated by Casein Kinase Iε, providing a molecular tool for investigating the role of Casein Kinase Iε in cellular processes. | ||||||
TAK 715 | 303162-79-0 | sc-362799 sc-362799A | 10 mg 50 mg | $185.00 $781.00 | ||
TAK 715 is a selective inhibitor of casein kinase I epsilon, characterized by its ability to disrupt the enzyme's phosphorylation activity. It engages in specific molecular interactions that stabilize the enzyme-substrate complex, leading to altered enzymatic kinetics. This compound uniquely influences downstream signaling cascades by modulating the phosphorylation state of target proteins, thereby providing a deeper understanding of cellular regulatory networks and their intricate dynamics. | ||||||
CR8, (S)-Isomer | 1084893-56-0 | sc-311307 | 5 mg | $201.00 | ||
CR8, the (S)-isomer, acts as a potent modulator of casein kinase I epsilon, exhibiting unique binding affinity that enhances its inhibitory effects. This compound selectively alters the enzyme's conformation, impacting its catalytic efficiency and substrate specificity. By fine-tuning phosphorylation events, CR8 influences critical cellular pathways, revealing insights into the regulatory mechanisms governing protein interactions and cellular responses. Its distinct kinetic profile further elucidates the enzyme's role in various biological processes. | ||||||
PF 670462 | 950912-80-8 | sc-204180 sc-204180A | 10 mg 50 mg | $198.00 $808.00 | 9 | |
PF-670462 is a highly selective inhibitor of Casein Kinase Iε. It functions by competitively inhibiting ATP binding to the kinase domain, resulting in the suppression of Casein Kinase Iε activity. | ||||||
CKI-7 dihydrochloride | 1177141-67-1 | sc-252621 sc-252621A | 5 mg 10 mg | $280.00 $320.00 | 5 | |
CKI-7 is a small molecule inhibitor of Casein Kinase I family, including Casein Kinase Iε. It disrupts the kinase activity by interfering with ATP binding, leading to the inhibition of Casein Kinase Iε-mediated phosphorylation. This inhibition affects downstream signaling events regulated by Casein Kinase Iε, providing insights into the cellular processes influenced by the kinase and serving as a pharmacological tool for functional studies. | ||||||
Cdc2-Like Kinase Inhibitor, TG003 | 300801-52-9 | sc-202528 sc-202528A | 5 mg 25 mg | $139.00 $548.00 | 6 | |
TG003 is a compound known for inhibiting Clk family kinases, including Casein Kinase Iε. It modulates alternative splicing by suppressing the activity of these kinases. While its primary target is Clk, TG003 can also affect Casein Kinase Iε, contributing to the modulation of its phosphorylation activity and subsequent cellular processes. This dual activity highlights the intricate connections between kinase signaling and alternative splicing regulation. | ||||||
PF 4800567 | 1188296-52-7 | sc-362782 sc-362782A | 5 mg 25 mg | $172.00 $492.00 | ||
PF-4800567 is a selective inhibitor of Casein Kinase I family members, including Casein Kinase Iε. By interfering with ATP binding to the kinase domain, PF-4800567 inhibits Casein Kinase Iε activity, modulating its downstream phosphorylation events. This selective inhibition provides a valuable tool for deciphering the specific functions of Casein Kinase Iε in cellular processes and unraveling its contributions to intracellular signaling networks. | ||||||
TBB | 17374-26-4 | sc-202830 sc-202830A sc-202830C sc-202830B sc-202830D | 10 mg 25 mg 50 mg 100 mg 250 mg | $245.00 $370.00 $454.00 $760.00 $1817.00 | 17 | |
4,5,6,7-Tetrabromobenzotriazole (TBB) is a compound that inhibits Casein Kinase I family members, including Casein Kinase Iε. It interferes with the ATP-binding site, leading to the inhibition of Casein Kinase Iε activity. This inhibition affects Casein Kinase Iε-mediated phosphorylation events, providing a molecular tool for studying the kinase's specific functions in cellular processes and unraveling its contributions to intracellular signaling networks. | ||||||