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CARD Inhibitors

CARD inhibitors, short for Caspase Activation and Recruitment Domain inhibitors, represent a specialized class of chemical compounds designed to target and modulate the CARD-containing proteins within cells. CARD domains are evolutionarily conserved protein motifs found in a variety of intracellular proteins, particularly those involved in apoptotic signaling pathways and innate immune responses. These domains facilitate protein-protein interactions, primarily through homotypic interactions, which are crucial for the formation of multi-protein complexes such as the apoptosome and inflammasomes. The CARD domain plays a pivotal role in the recruitment and activation of caspases, a family of cysteine proteases responsible for the execution of apoptosis and the processing of pro-inflammatory cytokines. Inhibitors that specifically target CARD domains are therefore integral to regulating the activity of CARD-containing proteins, thereby influencing the downstream signaling events they mediate. At a molecular level, CARD inhibitors are often designed to either interfere with the CARD-CARD interactions or to block the recruitment of downstream effector proteins. This interference can prevent the formation of functional protein complexes necessary for the activation of caspases or the assembly of inflammasomes, thereby modulating the cellular processes they control. The design of CARD inhibitors involves a deep understanding of the structural biology of CARD domains, including their binding interfaces and interaction dynamics. High-resolution techniques such as X-ray crystallography and NMR spectroscopy are frequently employed to elucidate the three-dimensional structures of CARD domains, providing insights into potential binding sites for inhibitors. The specificity and efficacy of these inhibitors are paramount, as CARD domains are involved in complex signaling networks, and off-target effects could lead to unintended cellular consequences. Thus, CARD inhibitors are crucial tools for probing the intricate signaling mechanisms within cells, allowing for the dissection of pathways critical to cellular homeostasis and immune responses.

Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Andrographolide	5508-58-7	sc-205594 sc-205594A	50 mg 100 mg	$15.00 $40.00	7	(1)
Andrographolide is a natural compound that modulates CAR indirectly. By influencing the NRF2 pathway, it can enhance the expression of antioxidant enzymes, which may compete with CAR for common coactivators, leading to the inhibition of CAR-mediated transcription.
PK 11195	85532-75-8	sc-203199 sc-203199A	10 mg 50 mg	$88.00 $321.00		(1)
PK11195 is a selective antagonist of the peripheral benzodiazepine receptor (PBR), indirectly affecting CAR. As PBR interacts with CAR in certain contexts, its antagonism by PK11195 may disrupt the functional association between PBR and CAR, resulting in the inhibition of CAR activity.
Ketoconazole	65277-42-1	sc-200496 sc-200496A	50 mg 500 mg	$63.00 $265.00	21	(1)
Ketoconazole is an antifungal agent in research that serves as a potent inhibitor of CYP3A4, an enzyme regulated by CAR. By inhibiting CYP3A4, ketoconazole can interfere with the metabolic activation of CAR, leading to the inhibition of CAR-mediated transcription and downstream effects.
Ellagic Acid, Dihydrate	476-66-4	sc-202598 sc-202598A sc-202598B sc-202598C	500 mg 5 g 25 g 100 g	$58.00 $95.00 $245.00 $727.00	8	(1)
Ellagic acid is a natural polyphenol that indirectly modulates CAR activity. By influencing the NRF2 pathway and enhancing the expression of antioxidant enzymes, ellagic acid may compete with CAR for common coactivators, resulting in the inhibition of CAR-mediated transcription.
Guggulsterone	95975-55-6	sc-203990 sc-203990A	10 mg 50 mg	$145.00 $615.00	1	(0)
Guggulsterone is a natural compound that indirectly modulates CAR activity. By influencing the PXR pathway, it may compete with CAR for common coactivators, leading to the inhibition of CAR-mediated transcription. Guggulsterone's impact on PXR can indirectly inhibit CAR by disrupting shared coactivator availability.
Lithocholic acid	434-13-9	sc-215262 sc-215262A	10 g 25 g	$100.00 $272.00	1	(1)
Lithocholic acid is a bile acid that serves as an endogenous ligand for FXR, indirectly influencing CAR. As FXR and CAR can crosstalk and compete for common coactivators, the activation of FXR by lithocholic acid may interfere with CAR-mediated transcription, leading to the inhibition of CAR activity.
Oltipraz	64224-21-1	sc-205777 sc-205777A	500 mg 1 g	$286.00 $622.00		(1)
Oltipraz is a synthetic antioxidant that indirectly modulates CAR activity. By activating the NRF2 pathway, it can enhance the expression of antioxidant enzymes, potentially leading to negative feedback and desensitization, resulting in the inhibition of CAR-mediated transcription.
D,L-Sulforaphane	4478-93-7	sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D	5 mg 10 mg 25 mg 1 g 10 g 250 mg	$153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00	22	(1)
Sulforaphane is a natural compound that indirectly modulates CAR activity. By activating the NRF2 pathway, it can enhance the expression of antioxidant enzymes, potentially leading to negative feedback and desensitization, resulting in the inhibition of CAR-mediated transcription.

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CARD Inhibitors

Andrographolide

PK 11195

Ketoconazole

Ellagic Acid, Dihydrate

Guggulsterone

Lithocholic acid

Oltipraz

D,L-Sulforaphane