CapZIP Activators
CapZIP activators are chemical compounds that primarily function by influencing the cAMP signaling pathway. They work by either directly stimulating adenylate cyclase, the enzyme responsible for cAMP synthesis, or by inhibiting phosphodiesterases (PDEs), a class of enzymes that degrade cAMP. In the former category, Forskolin is a prime example, being a direct activator of adenylate cyclase. This natural compound is capable of increasing intracellular cAMP levels, which in turn can activate CapZIP, a cAMP-responsive protein.
The second category of CapZIP activators is far more diverse and includes selective and non-selective PDE inhibitors. For instance, Rolipram and Etazolate are selective PDE4 inhibitors, while IBMX is a non-selective PDE inhibitor. These compounds increase cAMP levels by preventing its degradation, thus indirectly leading to CapZIP activation. Similarly, Vinpocetine, Cilostamide, Milrinone, and others function as inhibitors of different PDE types, all working to enhance cAMP levels and hence the functional activity of CapZIP. This array of CapZIP activators showcases the importance of the cAMP signaling pathway in the regulation of CapZIP and provides a comprehensive understanding of the different means by which this protein can be activated
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a natural compound that directly activates adenylate cyclase, an enzyme involved in the synthesis of cyclic AMP (cAMP). As CapZIP is a cAMP-responsive protein, enhancement of cAMP levels can result in the functional activation of CapZIP. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterases (PDE4), enzymes that degrade cAMP. By inhibiting PDE4, rolipram elevates cAMP levels in cells, which can lead to the activation of CapZIP. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases (PDEs), preventing the breakdown of cAMP and cGMP. This in turn can potentiate the activation of CapZIP due to increased cAMP levels. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine selectively inhibits PDE1, leading to an increase in intracellular cAMP levels. This can result in the activation of CapZIP, which is responsive to cAMP. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Cilostamide is a selective PDE3 inhibitor. By inhibiting PDE3, it increases cAMP levels, leading to the potential activation of CapZIP, a cAMP-responsive protein. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone is a PDE3 inhibitor used to increase cAMP levels. Elevated cAMP can activate CapZIP due to its cAMP-responsive nature. | ||||||
Etazolate Hydrochloride | 35838-58-5 | sc-201186 sc-201186A | 5 mg 25 mg | $60.00 $250.00 | 5 | |
Etazolate is a selective PDE4 inhibitor that increases cAMP levels. The increased cAMP can lead to the activation of CapZIP. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual inhibitor of PDE3 and PDE4. It enhances cAMP levels, which can lead to the activation of CapZIP. | ||||||
Siguazodan | 115344-47-3 | sc-201201 sc-201201A | 5 mg 25 mg | $100.00 $398.00 | ||
Siguazodan is a PDE3 inhibitor that increases cAMP levels, potentially leading to CapZIP activation. | ||||||
Piclamilast | 144035-83-6 | sc-478653 | 5 mg | $300.00 | ||
Piclamilast is a selective PDE4 inhibitor that increases cAMP levels. The increased cAMP can lead to the activation of CapZIP. | ||||||