CapZIP Antibody (3F6): sc-517059

CapZIP Antibody (3F6) is a mouse monoclonal IgG2a kappa light chain antibody that detects CapZIP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-CapZIP antibody (3F6) is available as the non-conjugated format. CapZIP, also known as RCSD1 (RCSD domain-containing protein 1) or MK2S4, is a 416 amino acid protein characterized by the presence of one RCSD domain and exists in two alternatively spliced isoforms. CapZIP plays a crucial role in regulating actin filament dynamics, particularly during cellular stress, by interacting with CapZ-α and CapZ-β, which are essential for stabilizing and remodeling F-actin structures. CapZIP′s ability to modulate actin assembly is vital for maintaining cellular integrity and facilitating various cellular processes, including motility and division. High expression levels of CapZIP are found in skeletal muscle, while lower levels are present in the spleen, thymus, and cardiac muscle. The gene encoding CapZIP is located on human chromosome 1, a region that spans 260 million base pairs and contains over 3,000 genes, many of which are associated with various diseases, including familial adenomatous polyposis and Parkinson′s disease. Notably, chromosome 1 is implicated in several cancers, such as head and neck cancer and malignant melanoma, highlighting the importance of studying proteins like CapZIP in understanding cellular functions and disease mechanisms.

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CapZIP Antibody (3F6) References:

1. Crystal structure of CapZ: structural basis for actin filament barbed end capping.  |  Yamashita, A., et al. 2003. EMBO J. 22: 1529-38. PMID: 12660160
2. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
3. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.  |  Eyers, CE., et al. 2005. Biochem J. 389: 127-35. PMID: 15850461
4. Chromosome 1 abnormalities in multiple myeloma.  |  Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
5. Structural basis of actin filament capping at the barbed-end: a cryo-electron microscopy study.  |  Narita, A., et al. 2006. EMBO J. 25: 5626-33. PMID: 17110933
6. A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia.  |  De Braekeleer, E., et al. 2007. Leukemia. 21: 2220-1. PMID: 17541395
7. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.  |  Cheung, CL., et al. 2009. Hum Mol Genet. 18: 679-87. PMID: 19064610