Molecular structure of Etazolate Hydrochloride, CAS Number: 35838-58-5
Etazolate Hydrochloride (CAS 35838-58-5)
See product citations (5)
Alternate Names:
SQ 20009
Application:
Etazolate Hydrochloride is a potent inhibitor of cAMP phosphodiesterase (PDE4) and less potent cGMP phosphodiesterase inhibitor
CAS Number:
35838-58-5
Purity:
≥98%
Molecular Weight:
325.79
Molecular Formula:
C14H19N5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Etazolate Hydrochloride is extensively studied in neurochemistry and molecular biology for its role as an inhibitor of phosphodiesterase. This compound is of interest for its potential to influence cyclic AMP levels within cells, which plays a significant role in various biochemical pathways. Research on Etazolate Hydrochloride often focuses on its molecular mechanism of action, particularly how it affects signaling pathways and cellular responses. Studies also explore the solubility and stability of Etazolate Hydrochloride in different experimental setups, ensuring optimal conditions for its use in laboratory experiments. Additionally, the impact of Etazolate Hydrochloride on cellular models is examined to understand its effects on cell physiology and molecular biology in controlled environments.
Etazolate Hydrochloride (CAS 35838-58-5) References
- Characteristics common to choleretic increments of bile induced by theophylline, glucagon and SQ-20009 in the dog. | Barnhart, JL. and Combes, B. 1975. Proc Soc Exp Biol Med. 150: 591-6. PMID: 174139
- Etazolate improves performance in a foraging and homing task in aged rats. | Drott, J., et al. 2010. Eur J Pharmacol. 634: 95-100. PMID: 20223232
- Comparison of benzodiazepine receptor binding in membranes from human or rat brain. | Sieghart, W., et al. 1985. Neuropharmacology. 24: 751-9. PMID: 3018615
- Adenosine antagonists as potential therapeutic agents. | Williams, M. and Jarvis, MF. 1988. Pharmacol Biochem Behav. 29: 433-41. PMID: 3283781
- 1-Ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009)--a potent new inhibitor of cyclic 3',5'-nucleotide phosphodiesterases. | Chasin, M., et al. 1972. Biochem Pharmacol. 21: 2443-50. PMID: 4345859
- In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes. | Placheta, P. and Karobath, M. 1980. Eur J Pharmacol. 62: 225-8. PMID: 6103810
- Interaction of putative anxiolytic agents with central adenosine receptors. | Williams, M., et al. 1981. Can J Physiol Pharmacol. 59: 897-900. PMID: 6117363
- Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. | Ahluwalia, GS. and Rhoads, AR. 1982. Biochem Pharmacol. 31: 665-9. PMID: 6177320
- Properties of adenylate cyclase and cyclic nucleotide phosphodiesterase in hamster isolated capillary preparations. | Nemecek, GM. 1980. Biochim Biophys Acta. 628: 125-35. PMID: 6244001
- Inhibition by etazolate (SQ 20009) and cartazolate (SQ 65396) of adenosine-stimulated [3H]cAMP formation in [2-3H]adenine-prelabeled vesicles prepared from guinea pig cerebral cortex. | Psychoyos, S., et al. 1982. Biochem Pharmacol. 31: 1441-2. PMID: 6284176
- Interaction of SQ 20009 and GABA-like drugs as modulators of benzodiazepine receptor binding. | Supavilai, P. and Karobath, M. 1980. Eur J Pharmacol. 62: 229-33. PMID: 6991258
- Motor nerve terminal facilitatory action of SQ 20009: an inhibitor of cyclic nucleotide phosphodiesterase. | Jacobs, RS. and McNiece, DM. 1977. J Pharmacol Exp Ther. 202: 404-10. PMID: 886471
- Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. | Wang, P., et al. 1997. Biochem Biophys Res Commun. 234: 320-4. PMID: 9177268
Inhibitor of:
CNBD2, PDE, and PDE7B.Activator of:
APOBEC4, BCNP1, CapZIP, CRISP-2, CSDA, GALR1, laeverin_4833403I15Rik, LHR, MPP3, nardilysin, PTG, RBM3, and UPase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Etazolate Hydrochloride, 5 mg | sc-201186 | 5 mg | $61.00 | |||
Etazolate Hydrochloride, 25 mg | sc-201186A | 25 mg | $255.00 |