CaMKII Inhibitors
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Items 11 to 16 of 16 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autocamtide-2 inhibitor | 167114-91-2 | sc-3117 | 1 mg | $95.00 | 1 | |
Autocamtide-2 Inhibitor selectively targets CaMKII by mimicking the enzyme's natural substrates, leading to competitive inhibition. This compound disrupts the phosphorylation cascade by preventing the enzyme from engaging with its activators, thereby altering downstream signaling pathways. Its distinct structural features allow for specific interactions with the ATP-binding site, influencing reaction kinetics and providing insights into calcium-mediated cellular regulation. | ||||||
12(S)-HPETE | 71774-10-2 | sc-200961A sc-200961 | 25 µg 50 µg | $153.00 $260.00 | ||
12(S)-HPETE is a bioactive lipid that plays a pivotal role in modulating CaMKII activity through its unique ability to interact with specific protein domains. This compound enhances the enzyme's phosphorylation capacity by stabilizing its active conformation, thereby influencing calcium signaling pathways. Its distinct stereochemistry allows for selective binding, which can alter reaction kinetics and promote diverse cellular responses, highlighting its significance in cellular signaling networks. | ||||||
K-252b | 99570-78-2 | sc-200585 sc-200585A | 100 µg 1 mg | $184.00 $612.00 | 1 | |
K-252b is a potent inhibitor of CaMKII, characterized by its unique binding affinity to the enzyme's regulatory domain. This interaction disrupts the calcium-dependent activation, leading to altered phosphorylation dynamics. K-252b's structural features facilitate specific molecular interactions that modulate downstream signaling pathways, influencing cellular processes. Its distinct mechanism of action provides insights into the intricate regulation of calcium signaling and the role of CaMKII in various cellular contexts. | ||||||
HA-1077 dihydrochloride | 203911-27-7 | sc-200583 sc-200583A | 10 mg 50 mg | $117.00 $482.00 | 4 | |
HA-1077 dihydrochloride acts as a selective inhibitor of CaMKII, exhibiting a unique mechanism that involves competitive binding to the enzyme's ATP-binding site. This interaction effectively alters the enzyme's phosphorylation activity, impacting calcium signaling pathways. The compound's structural characteristics enhance its affinity for the enzyme, leading to significant modulation of downstream effects in cellular signaling networks. Its kinetic profile reveals a distinct rate of inhibition, contributing to the understanding of CaMKII's regulatory roles in cellular functions. | ||||||
Arcyriaflavin A | 118458-54-1 | sc-202470 sc-202470A sc-202470B | 1 mg 10 mg 100 mg | $152.00 $292.00 $1796.00 | 4 | |
Arcyriaflavin A functions as a potent modulator of CaMKII, engaging in specific interactions that stabilize the enzyme's active conformation. Its unique binding dynamics facilitate allosteric regulation, influencing the enzyme's phosphorylation cascade. The compound's distinct structural features promote selective engagement with CaMKII, resulting in altered reaction kinetics that can fine-tune calcium-dependent signaling pathways. This nuanced modulation provides insights into the enzyme's complex regulatory mechanisms within cellular environments. | ||||||
CaM Kinase ll Inhibitor | sc-3039 | 0.5 mg/0.1 ml | $95.00 | 2 | ||
CaM Kinase II Inhibitor acts as a selective antagonist of CaMKII, disrupting its autophosphorylation and altering its conformational states. By binding to specific sites, it interferes with the enzyme's ability to interact with calcium and calmodulin, thereby modulating downstream signaling pathways. This inhibitor exhibits unique kinetics, leading to a reduction in the enzyme's activity and providing a deeper understanding of calcium-mediated cellular processes and their regulatory networks. | ||||||