Molecular structure of K-252b, CAS Number: 99570-78-2
K-252b (CAS 99570-78-2)
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Alternate Names:
Staurosporine Aglycone
Application:
K-252b is an antibiotic and a strong inhibitor of protein kinase C (PKC)
CAS Number:
99570-78-2
Purity:
≥98%
Molecular Weight:
453.45
Molecular Formula:
C26H19N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
K-252b is a general, cell permeable protein kinase inhibitor which acts by binding to the ATP binding domain of the kinase. K-252b is a potent inhibitor of CaMKII (Ca2+/calmodulin kinase II), MYLK (myosin light chain kinase, Ki=0.147 muM), PKA (cAMP- dependent protein kinase, Ki=0.09 muM), PKC (protein kinase C, Ki=0.02 muM), and cGKI (cGMP-dependent protein kinase, Ki=0.1 muM).
K-252b (CAS 99570-78-2) References
- Protein kinase C promotes spontaneous relaxation of streptolysin-O-permeabilized smooth muscle cells from the guinea-pig stomach. | Oishi, K., et al. 1999. Life Sci. 64: 1975-87. PMID: 10374923
- Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. | Saito, Y., et al. 1999. Mol Cell Endocrinol. 152: 65-72. PMID: 10432224
- Cooperativity between extracellular adenosine 5'-triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons. | Fujii, S., et al. 2002. Neuroscience. 113: 617-28. PMID: 12150781
- K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3. | Knüsel, B., et al. 1992. J Neurochem. 59: 715-22. PMID: 1629741
- K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons. | Knüsel, B. and Hefti, F. 1991. J Neurochem. 57: 955-62. PMID: 1861160
- Inhibition of nerve growth factor-induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane. | Nagashima, K., et al. 1991. FEBS Lett. 293: 119-23. PMID: 1959642
- K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. | Kase, H., et al. 1987. Biochem Biophys Res Commun. 142: 436-40. PMID: 3028414
- K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. | Nakanishi, S., et al. 1986. J Antibiot (Tokyo). 39: 1066-71. PMID: 3759658
- Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose. | Cheng, B., et al. 1994. J Neurochem. 62: 1319-29. PMID: 7510777
- A substrate of ecto-protein kinase is microtubule-associated protein 1B in cortical cell cultures undergoing synaptogenesis. | Muramoto, K., et al. 1994. Biochem Biophys Res Commun. 205: 1467-73. PMID: 7802683
- K-252b potentiation of neurotrophin-3 is trkA specific in cells lacking p75NTR. | Maroney, AC., et al. 1997. J Neurochem. 68: 88-94. PMID: 8978713
- Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophils. | Teshima, R., et al. 1997. J Immunol. 159: 964-9. PMID: 9218617
- Inhibition of glial cell line-derived neurotrophic factor induced intracellular activity by K-252b on dopaminergic neurons. | Pong, K., et al. 1997. J Neurochem. 69: 986-94. PMID: 9282920
Inhibitor of:
CaMKII, cGKI, MYLK, PKA, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
K-252b, 100 µg | sc-200585 | 100 µg | $184.00 | |||
K-252b, 1 mg | sc-200585A | 1 mg | $612.00 |