calsyntenin-1 Inhibitors
Calsyntenin-1 inhibitors represent a class of chemical compounds that specifically target and modulate the activity of the calsyntenin-1 protein within biological systems. Calsyntenin-1, a type I transmembrane protein primarily found in neuronal cells, plays a crucial role in intracellular protein trafficking and axonal transport, particularly in the context of synaptic function. The inhibition of calsyntenin-1 by these compounds offers insights into the fundamental processes governing cellular communication, with potential implications for various areas of neurobiology research.
These inhibitors typically function by binding to calsyntenin-1 and interfering with its normal cellular functions. By doing so, they can exert influence over various cellular processes, such as regulating the transport of neurotransmitter receptors and synaptic vesicles. This class of chemicals has become invaluable in the study of synaptic plasticity, neuronal development, and the intricate mechanisms underlying synaptic transmission. Researchers utilize calsyntenin-1 inhibitors as valuable tools to dissect the molecular pathways involved in synaptic signaling and vesicular trafficking, shedding light on the intricate interplay between different proteins within neurons. Consequently, calsyntenin-1 inhibitors have contributed significantly to our understanding of neurobiology, facilitating the exploration of neuronal communication mechanisms
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1 stabilizes axin by inhibiting the Wnt signaling pathway, potentially altering the cellular processes and pathways Calsyntenin-1 is involved in, such as synaptic function and neuronal connectivity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil blocks voltage-gated calcium channels, which can influence intracellular calcium levels, indirectly affecting the calcium-dependent functions of proteins like CLSTN1. | ||||||
Memantine hydrochloride | 41100-52-1 | sc-203628 | 50 mg | $68.00 | 4 | |
Memantine acts on the glutamatergic system by blocking NMDA receptors, which could alter synaptic plasticity and neurotransmission, processes in which CLSTN1 may play a role. | ||||||
Tideglusib | 865854-05-3 | sc-507358 | 10 mg | $75.00 | ||
Tideglusib inhibits glycogen synthase kinase-3 (GSK-3), which might modify the phosphorylation state of proteins related to CLSTN1 and affect synaptic function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits phosphatidylinositol 3-kinase (PI3K), which can influence intracellular signaling pathways and may affect the neuronal processes CLSTN1 is implicated in. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway, which could alter neuronal signaling and plasticity, potentially impacting the role of CLSTN1 in these processes. | ||||||
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione | 118876-58-7 | sc-478080 | 5 mg | $70.00 | 1 | |
NBQX blocks AMPA receptors, potentially altering glutamatergic signaling and synaptic transmission, which could indirectly affect processes that CLSTN1 is involved in. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $60.00 $75.00 $125.00 $205.00 | 8 | |
Sulfasalazine inhibits the nuclear factor kappa B (NF-κB) pathway, which might modify neuroinflammatory responses and thus indirectly affect neuronal processes that involve CLSTN1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase (ROCK), which could affect neurite outgrowth and cell migration, processes that may be influenced by CLSTN1. | ||||||