Calgranulin B Activators
Common Calgranulin B Activators include, but are not limited to 1α,25-Dihydroxyvitamin D3 CAS 32222-06-3, Zinc CAS 7440-66-6, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Retinoic Acid, all trans CAS 302-79-4 and PMA CAS 16561-29-8.
Calgranulin B activators are compounds or molecules that stimulate the activity or expression of Calgranulin B, which is also known as S100A9 or MRP14. Calgranulin B is a member of the S100 protein family, a group of small, calcium-binding proteins with diverse intracellular and extracellular functions. Calgranulin B, in particular, plays a pivotal role in immune regulation and inflammation. It is predominantly found in neutrophils and monocytes but can also be produced by other cell types in response to various stimuli. Calgranulin B can form heterodimers with Calgranulin A (S100A8), and together they make up the Calprotectin complex, which has been implicated in a range of biological processes.
Calgranulin B is known to participate in several cellular processes. It serves as a damage-associated molecular pattern (DAMP) molecule, which means that it can alert the immune system to tissue damage or infection when released from cells. Its ability to bind to Toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) on immune cells further underscores its role in immune activation. Calgranulin B is involved in the regulation of proinflammatory responses, leukocyte recruitment to inflamed tissues, and the modulation of cytokine production. Additionally, Calgranulin B has been linked to various pathological conditions, including inflammatory diseases, autoimmune disorders, and cancer.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This active form of vitamin D can induce the expression of Calgranulin B in certain cell types, particularly in the context of inflammation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Essential metal ion that can influence the expression of various genes, including those in the S100 family. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Bacterial endotoxin that can stimulate immune cells to release pro-inflammatory cytokines, which can then potentially upregulate Calgranulin B expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Derivative of vitamin A that can influence the expression of various genes, including potentially Calgranulin B. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Known to activate protein kinase C (PKC) and can lead to increased Calgranulin B expression in certain cell types. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
As an essential ion, calcium can influence numerous cellular pathways, potentially affecting the expression of calcium-binding proteins like Calgranulin B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound from turmeric with anti-inflammatory properties. It can modulate various gene expressions, potentially including Calgranulin B. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid that has anti-inflammatory effects. It can modulate the expression of various genes, potentially influencing Calgranulin B expression. | ||||||