Calgizzarin Activators
The chemicals listed are potential indirect activators or influencers of Calgizzarin (S100A11) activity. S100A11, being a calcium-binding protein, is likely influenced by changes in intracellular calcium levels and calcium signaling pathways. Compounds such as Forskolin, Thapsigargin, BAPTA-AM, Ionomycin, 2-Aminoethoxydiphenyl borate, and Nifedipine affect calcium signaling. Forskolin raises intracellular cAMP levels, which can lead to various downstream effects on calcium signaling. Thapsigargin and Ionomycin directly increase intracellular calcium levels, potentially impacting Calgizzarin's activity. BAPTA-AM, as a calcium chelator, and Nifedipine, a calcium channel blocker, modulate calcium availability, thereby potentially influencing Calgizzarin's function.
Trichostatin A and 5-Azacytidine affect chromatin structure and DNA methylation, respectively. These epigenetic modifiers could alter the expression of genes related to Calgizzarin or its interacting partners. Inhibitors like PD98059 (MEK/ERK pathway inhibitor), SB203580 (p38 MAPK inhibitor), and Y-27632 (ROCK inhibitor) target key signaling pathways in cells. These pathways might intersect with Calgizzarin's functions, particularly in cell proliferation, differentiation, and stress responses. Lastly, Lithium Chloride, known for its effects on GSK-3β and Wnt signaling, could indirectly modulate pathways relevant to Calgizzarin.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By increasing intracellular cAMP levels, Forskolin may indirectly influence Calgizzarin signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can modify chromatin structure and potentially affect Calgizzarin-related gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor might impact Calgizzarin activity by altering gene expression patterns. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of the MEK/ERK pathway, PD98059 could indirectly influence Calgizzarin through this signaling cascade. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, Y-27632 might impact Calgizzarin function by altering cytoskeletal dynamics. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, which could indirectly influence Calgizzarin by altering calcium homeostasis. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
As a calcium channel blocker, Nifedipine might indirectly impact Calgizzarin function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride, through its effect on GSK-3β and Wnt signaling, might influence pathways related to Calgizzarin. | ||||||