CACNG6 Inhibitors
CACNG6 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the CACNG6 protein, which is a subunit of voltage-gated calcium channels. The CACNG6 protein belongs to the transmembrane AMPA receptor regulatory protein (TARP) family, which plays a key role in modulating the function of calcium channels. These channels are essential for the regulation of calcium ion flow across the cell membrane, influencing various cellular processes such as electrical signaling, muscle contraction, and neurotransmitter release. Inhibition of CACNG6 impacts the activity of these channels, leading to alterations in calcium ion homeostasis, which can affect cellular signaling pathways.
The modulation of CACNG6 activity through its inhibitors provides insights into the intricate regulation of calcium channels, which are vital for proper physiological function. CACNG6, as part of the larger complex of calcium channels, contributes to the structural and functional properties of these channels, including their gating kinetics and expression at the cell surface. Inhibitors of CACNG6 can be used to investigate the specific role of this subunit in the broader context of calcium channel activity and how changes in this regulation affect cellular processes. The study of CACNG6 inhibitors helps to unravel the complex dynamics of calcium channels, offering a more detailed understanding of how calcium influx is controlled at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This chemical could hypothetically downregulate CACNG6 by hypermethylation of its promoter region, thereby silencing gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylases, this compound could tighten chromatin structure around the CACNG6 locus, leading to a decrease in its transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound might inhibit transcription of the CACNG6 gene by binding to DNA and obstructing the elongation phase of RNA polymerase. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting the mTOR pathway, rapamycin could reduce the expression of CACNG6 by decreasing the activity of transcription factors or translation of its mRNA. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib could indirectly reduce levels of CACNG6 by inhibiting the proteasome, which may stabilize proteins that repress CACNG6 transcription. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
This splicing inhibitor could lead to the production of aberrant CACNG6 mRNA variants, which could be rapidly degraded, resulting in decreased protein levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
By inhibiting RNA polymerase II, α-amanitin could decrease the synthesis of CACNG6 mRNA, leading to a reduction in the protein's expression. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib could inhibit the EGFR tyrosine kinase pathway, which may play a role in the expression of CACNG6, leading to its reduced transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to the downregulation of CACNG6 by targeting DNA methyltransferase enzymes, increasing methylation at the gene's promoter. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine might inhibit DNA and RNA polymerase enzymes, which could lead to a decrease in CACNG6 expression due to reduced transcription and mRNA stability. | ||||||