CaBP2 Activators
CaBP2 activators comprise a specific class of chemicals that influence the activity of CaBP2 by modulating calcium signaling pathways in the cellular environment. The calcium channel modulator FPL 64176, through its action to increase calcium channel activity, can indirectly support the enhancement of CaBP2 function by raising the availability of calcium ions for binding. Ryanodine and Thapsigargin, by increasing intracellular calcium via ryanodine receptors and inhibiting SERCA respectively, can enhance the action of CaBP2 in calcium-dependent signaling pathways. Compounds like Cyclopiazonic Acid and A23187 also work to raise cytosolic calcium, which in turn can augment the activity of CaBP2 due to its calcium-binding capabilities.
Additionally, BAY K 8644, an activator of L-type calcium channels, indirectly facilitates CaBP2 activity by boosting intracellular calcium, a crucial cofactor for CaBP2 function. On the other hand, SKF-96365 and 2-APB modulate receptor-mediated and store-operated calcium entry, respectively, which could lead to an elevated functional state of CaBP2 through the fine-tuning of calcium signaling. Lastly, Dantrolene serves to modulate CaBP2 activity by its action on ryanodine receptors, affecting calcium homeostasis and thereby potentially enhancing the regulatory role of CaBP2. These activators, through their varied but specific interactions with calcium signaling components, contribute to the functional enhancement of CaBP2, demonstrating their criticalroles in the modulation of calcium dynamics central to cellular signaling processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
FPL 64176 is a calcium channel modulator that increases calcium channel opening. Elevated calcium levels could enhance CaBP2's functional role in neurons by increasing its binding to calcium ions. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine locks ryanodine receptors in an open state, leading to increased intracellular calcium. This boost in calcium concentration can enhance the action of CaBP2 in modulating calcium-dependent signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), causing a rise in cytosolic calcium levels. This can indirectly enhance the function of CaBP2 by increasing its calcium-dependent activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is another inhibitor of SERCA, leading to an increase in cytosolic calcium levels and potentially enhancing the activation of CaBP2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration. This increase can enhance CaBP2 activity due to its calcium-dependent regulatory properties. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K 8644 is an L-type calcium channel activator, which leads to an increase in intracellular calcium levels. This can indirectly enhance CaBP2 activity by increasing calcium availability for binding. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry, which could indirectly lead to the activation of compensatory calcium signaling pathways, enhancing CaBP2 function. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB modulates store-operated calcium entry, potentially leading to changes in calcium dynamics that enhance the functional activity of CaBP2. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, which may lead to an indirect enhancement of CaBP2 activity by altering intracellular calcium homeostasis. | ||||||