C9orf79 Inhibitors
Inhibition of C9orf79 can be achieved through the modulation of various signaling pathways and cellular processes to which this protein is connected. Compounds that inhibit kinases could impede phosphorylation events, potentially affecting C9orf79's role in signal transduction and leading to its functional inhibition. For instance, targeting key components of the MAPK/ERK and PI3K signaling cascades can alter cellular responses to cytokines and stress, which may indirectly influence C9orf79's activity. Similarly, inhibition of mTOR signaling can suppress translation regulation mechanisms that might involve this protein. Additionally, specific inhibition of protein kinases such as EGFR tyrosine kinase could interfere with downstream signaling, affecting proliferation processes possibly associated with C9orf79.
Inhibitors that target other kinases, like JNK, involved in apoptosis, or ROCK, which affects cytoskeleton organization, could also lead to the suppression of C9orf79 activity if it is linked to these cellular processes. The disturbance of cell cycle regulation by inhibiting Aurora kinases may further impact C9orf79 function, assuming its involvement in cell cycle control. Beyond kinase inhibition, regulating cell survival and proliferation pathways through compounds that target signaling proteins like AKT can also result in the indirect inhibition of C9orf79.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that targets multiple protein kinases, leading to inhibition of phosphorylation processes that C9orf79 may be involved in. This inhibition could affect C9orf79's role in signal transduction. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3K), which are upstream of several signaling pathways. Inhibition of PI3K could affect the signaling cascades that regulate the function or localization of C9orf79. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can suppress the mTOR signaling pathway, potentially affecting the translation regulation mechanisms that C9orf79 might be associated with. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2, which are key components of the MAPK/ERK pathway. The suppression of this pathway could indirectly inhibit C9orf79 if it is linked to downstream signaling events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAP kinase which is involved in the regulation of cellular responses to cytokines and stress, potentially influencing C9orf79 activity if it's part of these responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK specifically blocking the MAPK/ERK pathway, which could indirectly inhibit C9orf79 if it is involved in processes regulated by this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which modulates cellular processes such as apoptosis. If C9orf79 is involved in these processes, inhibition of JNK could lead to its functional inhibition. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of ROCK kinases, leading to changes in cytoskeleton organization. If C9orf79 is associated with cytoskeletal dynamics, its function could be indirectly inhibited. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
An EGFR tyrosine kinase inhibitor that could interfere with downstream signaling affecting cellular processes like proliferation, which may involve C9orf79. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor, which by disrupting cell cycle regulation could also indirectly affect C9orf79 function if it is involved in cell cycle control. | ||||||