C9orf72 Inhibitors
The class of chemicals described as C9orf72 inhibitors encompasses a diverse range of compounds that indirectly modulate the activity of C9orf72. These chemicals mainly exert their inhibitory effects through the disruption of various cellular pathways such as autophagy, intracellular trafficking, and protein synthesis, each of which can indirectly impact the functional dynamics of C9orf72. Since C9orf72 is involved in crucial cellular processes, these inhibitors are not selective for C9orf72; instead, they affect broader cellular mechanisms, which in turn can modulate the activity of C9orf72. The inhibitors vary in their targets and mechanisms, ranging from autophagy inhibition, which impedes the lysosomal degradation process vital for cell survival and homeostasis, to translation initiation, which affects the synthesis of all proteins within the cell, altering C9orf72 levels or its functional partners.
The compounds identified do not bind directly to C9orf72 but are involved in key processes that are crucial for the normal functioning of C9orf72. For example, inhibitors of the autophagic pathway can lead to an accumulation of substrates that would normally be processed by C9orf72, thereby affecting its normal function. Other chemicals act by inhibiting enzymes or blocking pathways that are upstream or parallel to those involving C9orf72, which can result in a change in the cellular environment and indirectly impact C9orf72 activity. It is through these complex and interconnected pathways that these inhibitors exert their effects on C9orf72 activity, making them significant in the study of cellular processes and disease pathogenesis related to the function of C9orf72.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-methyladenine inhibits autophagy through its action on class III phosphatidylinositol 3-kinase (PI3K). Since C9orf72 is linked to the regulation of autophagy, the inhibition of this pathway can indirectly reduce the functional activity of C9orf72, which is believed to be associated with autophagy regulation in neurons. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor which, by reducing autophagy, can have implications on the functional dynamics of C9orf72. Given that C9orf72 has been implicated in the process of autophagy, Wortmannin’s action can lead to an indirect reduction in C9orf72 activity. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 is a potent autophagy inhibitor that works by targeting ubiquitin-specific peptidase 10 (USP10) and USP13, which can regulate the degradation of PI3K. Inhibiting autophagy could potentially downregulate C9orf72 activity indirectly, as C9orf72 is thought to play a role in this cellular process. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) and inhibits the late stage of autophagy. This can interfere with the function of C9orf72 in autophagy, leading to an indirect modulation of its activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an autophagy inhibitor that prevents endosome-lysosome fusion, an essential step in autophagy. By blocking this step, chloroquine can indirectly influence C9orf72 activity related to this pathway. | ||||||
Lys05 | 1391426-24-6 | sc-507532 | 5 mg | $140.00 | ||
Lys05 is a dual PI3K/mTOR inhibitor and a more potent derivative of chloroquine. It disrupts lysosome acidification, which is crucial for autophagy, potentially modulating C9orf72-related functions. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor which can alter the homeostasis of cellular proteins, including C9orf72. While not directly inhibiting C9orf72, it can interfere with pathways where new protein synthesis is required, thereby potentially decreasing C9orf72 levels. | ||||||
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $136.00 $541.00 | ||
Ciliobrevin A is a Hedgehog (Hh) signaling pathway antagonist that specifically targets dynein motor function. While C9orf72 is not in the Hh pathway, C9orf72 has been implicated in cytoskeletal organization and intracellular trafficking, processes where dynein is crucial. Therefore, Ciliobrevin A may indirectly affect C9orf72's cellular roles. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can affect calcium homeostasis in cells. While it is primarily used for cardiovascular diseases, its role in modulating calcium levels can have downstream effects on various cellular pathways, including those associated with C9orf72 activity. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide, a natural product from Aglaia species, has been shown to inhibit translation initiation. Given the relationship between protein synthesis and the potential modulation of C9orf72, this compound could indirectly influence C9orf72 levels or activity by affecting the translation of proteins involved in pathways where C9orf72 is active. | ||||||