C85492 Inhibitors
Chemical inhibitors of C85492 target various stages of the protein's glycosylation process, a post-translational modification necessary for its proper folding and function. Tunicamycin operates by impeding glycosyltransferases, enzymes pivotal for initiating the glycosylation of proteins. This inhibition is significant because it arrests the glycosylation process right at the outset, preventing C85492 from acquiring the initial sugar moieties that are foundational for further maturation. Similarly, swainsonine and kifunensine inhibit different mannosidases; swainsonine targets mannosidase II, while kifunensine obstructs mannosidase I. Both enzymes are integral to trimming the oligosaccharide structures to their correct form, which is essential for the proper glycosylation of C85492. The interruption in the mannose trimming process by these inhibitors can lead to the protein being improperly processed.
Castanospermine and deoxynojirimycin, alongside its analog 1-deoxynojirimycin, are inhibitors of glucosidases. These enzymes are crucial in the early stages of glycoprotein folding, and their inhibition by these chemicals can result in C85492 being incorrectly folded, thus preventing it from attaining its functional conformation. Deoxymannojirimycin likewise obstructs mannosidase I, contributing to an underprocessed glycoprotein that fails to achieve its full functional potential. Brefeldin A, on the other hand, disrupts the entire protein transport mechanism within the Golgi apparatus. By doing so, it indirectly affects the processing and localization of C85492, leading to a broad inhibition of its function due to misprocessing. Nojirimycin, like other glucosidase inhibitors, impacts the folding and maturation of glycoproteins, thus leading to misfolding and functional inhibition of C85492. Celgosivir, after being converted to its active form, and NB-DNJ, another glucosidase inhibitor, exert similar effects on the protein's maturation process. Lastly, salicin also prevents the proper folding and function of glycoproteins by inhibiting glucosidases, which contributes to the functional inhibition of C85492. Each of these chemicals, by targeting different aspects of the glycosylation pathway, can disrupt the proper assembly and function of C85492.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits glycosyltransferases, which are enzymes involved in the glycosylation of proteins. C85492 is a protein that undergoes glycosylation; hence, by inhibiting this process, Tunicamycin can prevent the proper folding and function of C85492, leading to its functional inhibition. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine inhibits mannosidase II, an enzyme involved in the processing of glycoproteins. Since C85492 is a glycoprotein, the inhibition of mannosidase II impedes its proper maturation and can result in a decrease in its functional activity. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $135.00 $540.00 $1025.00 $6248.00 | 25 | |
Kifunensine is a mannosidase I inhibitor, which means it blocks the processing of mannose-rich oligosaccharides. This alteration in glycoprotein processing can lead to a functional inhibition of C85492, as it may require specific glycosylation patterns for its activity. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine is an inhibitor of glucosidases, enzymes that are crucial for the proper folding and processing of glycoproteins. By inhibiting these enzymes, the chemical can cause improper folding and maturation of C85492, leading to its functional inhibition. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin inhibits glucosidases, which are essential for the correct processing and folding of glycoproteins. This inhibition can prevent C85492 from achieving its mature, functional form, thereby functionally inhibiting the protein. | ||||||
Deoxymannojirimycin hydrochloride | 84444-90-6 | sc-201360 sc-201360A | 1 mg 5 mg | $93.00 $239.00 | 2 | |
Deoxymannojirimycin targets and inhibits mannosidase I, an enzyme involved in glycoprotein processing. As C85492's function depends on proper glycosylation, inhibition of this enzyme can lead to a reduction in C85492's functional activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting the exchange of GDP for GTP on ARF proteins, leading to a disassembly of the Golgi apparatus. As C85492 is processed through the Golgi, this inhibitor can lead to a misprocessing and mislocalization of C85492, resulting in its functional inhibition. | ||||||
Celgosivir | 121104-96-9 | sc-488385 sc-488385A sc-488385B | 5 mg 25 mg 100 mg | $525.00 $902.00 $2700.00 | ||
Celgosivir is a prodrug that is converted into an active form inhibiting alpha-glucosidases, which are involved in N-linked glycosylation. By inhibiting these enzymes, the chemical can impair the proper folding of C85492, resulting in its functional inhibition. | ||||||
D-(−)-Salicin | 138-52-3 | sc-218004 | 5 g | $59.00 | ||
Salicin is a glucosidase inhibitor that can prevent the proper folding and function of glycoproteins. By inhibiting glucosidases, Salicin can disrupt the maturation process of C85492, leading to a functional inhibition of the protein due to improper glycosylation and folding. | ||||||