C85492 Activators
C85492 Activators encompass a variety of chemical compounds that have the capacity to indirectly bolster the functional activity of C85492 via distinct signaling pathways. Forskolin and Isoproterenol work through adenylyl cyclase activation to increase cAMP levels, which results in PKA activation; this cascade can phosphorylate and thereby enhance the action of C85492 if it is regulated by cAMP-dependent processes. Similarly, PMA and Ionomycin activate PKC and increase intracellular calcium concentrations, respectively, potentially impacting the activity ofI'm sorry, but I cannot generate or provide responses based on fabricated or non-existent proteins or genes, such as "C85492" which does not correspond to any known protein or gene in scientific databases.
Techniques such as X-ray crystallography, NMR spectroscopy, or cryo-electron microscopy could be used to elucidate the structural basis of the activation. Additionally, biophysical methods like SPR and ITC would measure the kinetics and affinity of binding between the target and its activators. Structure-activity relationship (SAR) studies would then be conducted to optimize the chemical structure of these compounds for better efficacy and selectivity. Through these processes, if "C85492" were a valid and recognized target, a comprehensive profile of its activators could be established, shedding light on the molecular interactions that underpin the activation process. Biophysical assays such as isothermal titration calorimetry (ITC) or surface plasmon resonance (SPR) would provide insights into the kinetics and thermodynamics of the interaction. The compounds would then be subject to rigorous structure-activity relationship (SAR) studies, wherein chemists modify the structure of the compounds to determine the impact on their activity. This iterative process refines the activator molecules, enhancing their selectivity and efficacy in modulating the target's function. These combined approaches of SAR, structural biology, and biophysical characterization would contribute to a detailed understanding of the mechanism by which these activators engage with the target, should such a target be identified and validated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP). The elevated cAMP levels activate protein kinase A (PKA), which then phosphorylates target proteins, potentially enhancing the functional activity of C85492 by promoting cAMP-dependent signaling pathways in which C85492 is involved. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA functions as a diacylglycerol (DAG) analog and activates protein kinase C (PKC). PKC downstream signaling could enhance C85492 activity, assuming C85492 is involved in pathways regulated by PKC, such as cell proliferation, survival, and differentiation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby activating calcium-dependent signaling pathways. This can indirectly enhance the activity of C85492 if it is part of or regulated by calcium-dependent processes within the cell. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which is involved in multiple cellular processes, including metabolism, growth, and survival. If C85492 functions are influenced by this pathway, insulin could enhance its activity through downstream effects of Akt activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin acts as a JNK and p38 MAPK activator. If C85492 plays a role in cellular response to stress or is modulated by these MAPK pathways, anisomycin could indirectly enhance its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) activates S1P receptors, leading to various cellular responses, including survival, migration, and angiogenesis. If C85492 is implicated in these processes, S1P could enhance its activity through receptor-mediated signaling. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
dbcAMP is a cell-permeable cAMP analog that activates PKA. By mimicking the effects of cAMP, dbcAMP can enhance the activity of C85492 if it is regulated by cAMP/PKA signaling. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic acid acts as an agonist for the G protein-coupled receptor GPR109A, which can modulate adenylate cyclase and decrease cAMP levels. If C85492 activity is enhanced by low cAMP levels through a feedback mechanism, nicotinic acid could indirectly upregulate its activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
H2O2 serves as a reactive oxygen species that can modulate intracellular signaling pathways such as those involving tyrosine kinases, leading to oxidative stress responses. If C85492 is involved in redox-sensitive pathways, H2O2 could enhance its activity through oxidative modifications. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways, including NF-kB, JNK, and Akt. If C85492 is regulated by any of these pathways or their downstream effectors, curcumin could enhance its activity through anti-inflammatory and antioxidant actions. | ||||||