C4ST-2 Activators
Chondroitin 4-sulfotransferase 2 (C4ST-2) is an enzyme that plays a vital role in the biosynthesis of chondroitin sulfate, a key component of the extracellular matrix found in connective tissues such as cartilage. This enzyme specifically catalyzes the transfer of sulfate groups to the C4 position of the N-acetylgalactosamine (GalNAc) residues in chondroitin. The sulfation pattern of chondroitin sulfate is critical for its biological function, influencing its ability to interact with a variety of proteins, including growth factors and cytokines.
C4ST-2 is part of the glycosaminoglycan (GAG) biosynthetic pathway, which is essential for creating diverse GAG chains that contribute to the structural integrity and function of the extracellular matrix. The activity of C4ST-2 thus affects the physical properties of cartilage, such as elasticity and resistance to compression, and plays a role in cellular signaling pathways that govern tissue development, maintenance, and repair.The expression of C4ST-2 is regulated by various factors, including developmental signals, cytokines, and growth factors. Alterations in C4ST-2 activity have been implicated in pathological conditions such as osteoarthritis, where changes in chondroitin sulfate composition can affect cartilage function and integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression related to cell differentiation and may impact C4ST-2 expression in developing tissues. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Vitamin C is a cofactor for enzymes involved in collagen synthesis and may indirectly affect C4ST-2 expression by influencing the extracellular matrix. | ||||||
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $197.00 $764.00 | ||
Glucosamine is a building block for glycosaminoglycans and may upregulate C4ST-2 as part of its biosynthetic pathway. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estrogen can modulate connective tissue metabolism, potentially affecting C4ST-2 expression in hormone-responsive tissues. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, may influence extracellular matrix components and alter C4ST-2 expression. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 plays a role in inflammation and healing processes, which could involve the regulation of C4ST-2 expression. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Hypoxic conditions can lead to extracellular matrix remodeling, potentially affecting C4ST-2 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as an HDAC inhibitor, which can lead to chromatin remodeling and affect gene expression, including C4ST-2. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
Thyroid hormones regulate metabolic processes and could influence C4ST-2 expression in connective tissue. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects glycogen synthase kinase-3 (GSK-3) signaling, which may intersect with pathways regulating C4ST-2 expression. | ||||||