C3b Inhibitors
C3b inhibitors are a class of chemical compounds that specifically target the C3b protein, a central component of the complement system involved in immune defense and the clearance of pathogens. C3b is generated from the cleavage of the complement protein C3 and plays a crucial role in opsonization, a process where pathogens are marked for destruction by immune cells. C3b binds to pathogen surfaces, facilitating their recognition and removal by phagocytic cells. Inhibitors of C3b work by blocking the active sites of the protein or interfering with its binding to pathogens or immune receptors. By inhibiting these interactions, C3b inhibitors disrupt the complement activation pathways, allowing researchers to study the precise role of C3b in immune processes and pathogen recognition.
The development of C3b inhibitors involves detailed studies of the protein's structure, particularly the regions responsible for its interaction with other proteins in the complement cascade and the surfaces of pathogens. These inhibitors are often small molecules, peptides, or biologics designed for high specificity to ensure they precisely target C3b without affecting other complement proteins. Through the use of these inhibitors, scientists can modulate the activity of the complement system and explore the biological consequences of C3b inhibition, such as changes in immune response, inflammation, and cellular communication. C3b inhibitors are valuable tools for dissecting the mechanisms of complement activation and understanding the broader implications of complement regulation in various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone can downregulate the transcription of the C3 gene by altering the activity of transcription factors such as NF-κB, which are involved in the immune response, potentially resulting in decreased synthesis of C3b. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin selectively inhibits mTORC1, a key regulatory kinase for mRNA translation, which could lead to a reduction in the production of proteins including the C3 component, thereby possibly lessening the generation of C3b. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A binds to the cytosolic protein cyclophilin, inhibiting calcineurin, which could lead to the suppression of IL-2 and other cytokines, potentially resulting in a decrease in the C3 gene expression and subsequently lower levels of C3b. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid interacts with retinoic acid receptors that bind to retinoic acid response elements in DNA, which could lead to the suppression of genes involved in the immune response, potentially including the gene coding for C3 and thus reducing C3b synthesis. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its hormonal form calcitriol, binds to the vitamin D receptor, which may decrease the expression of genes involved in inflammation, potentially leading to reduced transcription of the C3 gene and lower levels of C3b. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone acts as a glucocorticoid receptor agonist which can repress the expression of genes that encode for inflammatory mediators and proteins, potentially suppressing the C3 gene expression and consequently decreasing C3b levels. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, leading to reduced purine synthesis, which could suppress the proliferation of cells involved in the immune response, potentially resulting in decreased C3 gene transcription and subsequent C3b production. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Docosahexaenoic acid (DHA) can decrease the expression of inflammatory genes by altering cell membrane composition and cellular signaling, possibly leading to reduced transcription of the C3 gene and lower C3b production. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin inhibits cyclooxygenase enzymes, which could lead to a decrease in the synthesis of prostaglandins and thromboxanes, potentially downregulating the expression of genes associated with the inflammatory response, including the gene for C3, thereby reducing C3b levels. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide inhibits the production of tumor necrosis factor-alpha (TNF-α) and may suppress other inflammatory cytokines, potentially leading to the downregulation of the C3 gene and a consequent decrease in C3b. | ||||||