C230097I24Rik Activators
Zscan30, a zinc finger and SCAN domain-containing protein orthologous to human ZSCAN30, plays a pivotal role in cellular processes. The zinc finger and SCAN domains suggest its involvement in transcriptional regulation, making it a key player in controlling gene expression. The activation of Zscan30 is a finely tuned process influenced by various chemical compounds. Direct activators like Retinoic Acid, Dexamethasone, and ATRA directly engage with Zscan30 through specific receptors, modulating its DNA binding and transcriptional regulatory activities. Indirect activators, such as Sodium Butyrate, Trichostatin A, and Forskolin, impact Zscan30 through epigenetic modifications, histone acetylation, and cAMP-PKA pathway activation, respectively. These alterations facilitate Zscan30's access to target genes, contributing to transcriptional regulation.
The intricate network of indirect activators, including Nicotinamide, Valproic Acid, 5-Azacytidine, Sodium Valproate, Butyric Acid, and Prostaglandin E2, influences Zscan30 through various pathways such as NAD+-dependent SIRT1, DNA demethylation, and EPAC. These compounds collectively contribute to the modulation of Zscan30's activity, ensuring its participation in cellular processes associated with its zinc finger and SCAN domain. In conclusion, the activation of Zscan30 is a complex interplay of direct and indirect activators, finely regulating its role in transcriptional regulation. Understanding these chemical influences provides valuable insights into the molecular mechanisms underlying Zscan30's function, paving the way for further exploration of its involvement in cellular processes and potential implications in broader biological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A vitamin A derivative that acts as a direct activator of Zscan30 by binding to retinoic acid receptors. This complex translocates to the nucleus, influencing transcriptional activity. Zscan30, being a zinc finger and SCAN domain-containing protein, responds to retinoic acid, leading to enhanced DNA binding and regulation of target genes critical for cellular functions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A short-chain fatty acid that indirectly activates Zscan30 by influencing histone acetylation. Sodium Butyrate inhibits histone deacetylases, promoting an open chromatin state. This epigenetic modification allows Zscan30 to access its target genes, participating in transcriptional regulation. The activation of Zscan30 contributes to cellular processes influenced by its zinc finger and SCAN domain, crucial for proper cellular function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid that directly activates Zscan30 by binding to glucocorticoid receptors. This complex translocates to the nucleus, modulating gene expression. Zscan30, as a zinc finger and SCAN domain-containing protein, responds to dexamethasone, leading to enhanced DNA binding and transcriptional regulation of target genes essential for cellular processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that indirectly activates Zscan30 by promoting histone acetylation. Trichostatin A alters chromatin structure, allowing Zscan30 to access its target genes and participate in transcriptional regulation. The activation of Zscan30 is crucial for cellular processes influenced by its zinc finger and SCAN domain, contributing to proper cellular function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of vitamin B3 that indirectly activates Zscan30 by influencing the NAD+-dependent SIRT1 pathway. Nicotinamide inhibits SIRT1, affecting histone deacetylation. This epigenetic modification facilitates Zscan30 access to its target genes, contributing to transcriptional regulation. The activation of Zscan30 is essential for cellular processes influenced by its zinc finger and SCAN domain, ensuring proper cellular function. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A histone deacetylase inhibitor that indirectly activates Zscan30 by promoting histone acetylation. Valproic Acid alters chromatin structure, allowing Zscan30 to access its target genes and participate in transcriptional regulation. The activation of Zscan30 is crucial for cellular processes influenced by its zinc finger and SCAN domain, contributing to proper cellular function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA demethylating agent that indirectly activates Zscan30 by altering DNA methylation patterns. 5-Azacytidine promotes an open chromatin state, allowing Zscan30 access to its target genes and participation in transcriptional regulation. The activation of Zscan30 is essential for cellular processes influenced by its zinc finger and SCAN domain, ensuring proper cellular function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
A short-chain fatty acid that indirectly activates Zscan30 by influencing histone acetylation. Butyric Acid inhibits histone deacetylases, promoting an open chromatin state. This epigenetic modification allows Zscan30 to access its target genes, participating in transcriptional regulation. The activation of Zscan30 contributes to cellular processes influenced by its zinc finger and SCAN domain, crucial for proper cellular function. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
A lipid mediator that indirectly activates Zscan30 through the EPAC pathway. Prostaglandin E2 stimulates EPAC, leading to cAMP production and subsequent activation of Zscan30. This influences its phosphorylation status and enhances DNA binding, playing a vital role in cellular processes associated with its zinc finger and SCAN domain. | ||||||