C20orf26 Activators

Cilia and flagella associated protein 61, also recognized by its gene symbol CFAP61, is a protein that in humans is encoded by the CFAP61 gene. This protein is part of a group of proteins that are associated with the structure and function of cilia and flagella, which are hair-like organelles protruding from the surface of many eukaryotic cells. Cilia and flagella play critical roles in motility, sensory perception, and signal transduction, and they are essential for various physiological processes.

CFAP61 is believed to contribute to the assembly or stability of cilia and flagella. Cilia can be categorized into two types: motile and non-motile (or primary) cilia. Motile cilia are often involved in movement, either of the cell itself, as seen in the sperm flagellum, or of the surrounding fluid, such as the cilia lining the human respiratory tract that help clear mucus. Non-motile cilia, on the other hand, are important for sensing environmental signals and are involved in various signaling pathways. Defects in ciliary proteins, including those associated with CFAP61, can lead to a spectrum of disorders known as ciliopathies. These can manifest in a range of presentations, including respiratory issues, reduced fertility, sensory deficits, and others. The exact molecular function of CFAP61 within the cilia is not fully understood, but like other ciliary proteins, it may be involved in the construction of the axoneme-the structural core of cilia and flagella-or in the regulation of ciliary movement and signaling.