C20orf134 Inhibitors

ctin-like 10, often abbreviated as ACTL10 or ACTL6B, is a member of the actin family of proteins and shares considerable sequence homology with conventional actin. Despite this similarity, ACTL10 possesses unique features that distinguish it from the globular and filamentous forms of actin typically involved in cytoskeletal structure and cell motility.ACTL10 is particularly known for its role in chromatin remodeling as a component of the BAF (BRG1/BRM-associated factor) complex, which is pivotal for the regulation of gene expression by altering the chromatin structure, thereby controlling the accessibility of transcription factors to DNA. It functions as a scaffold in the BAF complex, providing structural support for the assembly of other subunits and enabling the complex to exert its effects on chromatin architecture.

The protein is widely expressed in various tissues and is essential for several developmental processes. Studies have shown that mutations or alterations in the ACTL10 gene can have significant implications for human health, including associations with neurodevelopmental disorders and possibly impacting oncogenic processes.As a chromatin remodeling factor, ACTL10 plays a critical part in the epigenetic regulation of gene expression. It does not directly bind to DNA but influences DNA accessibility indirectly through its action within the BAF complex. The dynamic remodeling of chromatin by ACTL10-containing complexes facilitates essential cellular processes such as differentiation, proliferation, and response to DNA damage.