C12orf12 Activators
Chemical activators of C12orf12 can engage various intracellular signaling pathways to modulate the protein's activity. Phorbol 12-myristate 13-acetate (PMA) can activate protein kinase C (PKC), which in turn can catalyze the phosphorylation of C12orf12, leading to its activation. Similarly, forskolin acts by elevating cAMP levels within the cell, which activates protein kinase A (PKA). PKA then can phosphorylate C12orf12 or other proteins within the same pathway, which is integral to C12orf12 activation. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent protein kinases that may directly phosphorylate C12orf12. Thapsigargin operates by preventing the sequestration of calcium into the endoplasmic reticulum, resulting in increased cytosolic calcium that activates kinases capable of C12orf12 phosphorylation. Okadaic Acid, by inhibiting protein phosphatases, prevents the dephosphorylation of proteins, including C12orf12, which can lead to its activation due to prolonged phosphorylated state.
Anisomycin can activate C12orf12 through its role in stimulating stress-activated protein kinases, which may target C12orf12 for phosphorylation. (-)-Epigallocatechin gallate (EGCG) can lead to the activation of C12orf12 by inhibiting certain protein kinases, potentially causing a compensatory upregulation of alternative kinases that can activate C12orf12. Bisindolylmaleimide I, as a PKC inhibitor, can also result in C12orf12 activation through the induction of compensatory signaling mechanisms. Calyculin A, similar to Okadaic Acid, can maintain proteins in a phosphorylated state, including C12orf12, leading to its activation. Brefeldin A disrupts the Golgi apparatus, which can activate stress pathways and kinases that may phosphorylate C12orf12. Lastly, 8-Bromo-cAMP and Dibutyryl-cAMP, both cAMP analogs, activate PKA, which can then directly or indirectly lead to the phosphorylation and subsequent activation of C12orf12.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can lead to the activation of C12orf12 through downstream signaling pathways that involve PKC-mediated phosphorylation events. PKC is known to phosphorylate a wide range of substrates, including proteins similar to C12orf12. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases could phosphorylate C12orf12 directly or activate it through phosphorylation of proteins within the same signaling pathway. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the SERCA pump, causing an increase in cytosolic calcium that activates calcium-dependent kinases. These kinases could then activate C12orf12 through phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a protein phosphatase inhibitor which could lead to sustained phosphorylation of proteins including C12orf12, resulting in its activation due to the prevention of dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases which may phosphorylate C12orf12 as part of the stress response signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit certain types of protein kinases, which might result in the activation of compensatory pathways that activate C12orf12 through phosphorylation by upregulated kinases. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor that could lead to the activation of C12orf12 by inducing a compensatory response in cellular signaling pathways, which may include the activation of alternative kinases that phosphorylate C12orf12. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor that can lead to the increased phosphorylation state of cellular proteins including C12orf12, potentially leading to its activation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus, which could lead to activation of stress pathways that include kinases capable of phosphorylating C12orf12 or activating it through other proteins in the same pathway. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cAMP analog that activates PKA, which may then phosphorylate C12orf12 or proteins within its signaling pathway leading to C12orf12 activation. | ||||||