Date published: 2026-2-14

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C11orf20 Activators

The chemical class referred to as C11orf20 activators encompasses various compounds that can influence the activity of the C11orf20 protein, an auxiliary subunit of the CATSPER channel, which is known to play a crucial role in sperm motility and fertility. These activators can mediate their effects through different mechanisms, including altering intracellular signaling cascades, modulating ion concentrations, and affecting the cellular environment. For instance, certain activators within this class function by raising intracellular pH levels, which in turn can enhance the activity of the CATSPER channels. Others operate by increasing the intracellular concentration of second messengers like cAMP, which can prompt protein kinase A (PKA) activation, subsequently affecting the CATSPER channels and thus the function of C11orf20.

Moreover, some members of this class act by binding to and modulating receptors or ion channels, leading to changes in calcium influx, a key regulator of sperm motility. These activators can also impact the bioavailability of ions such as zinc, which is implicated in sperm capacitation and may have a role in the regulation of the CATSPER channels. By affecting the CATSPER channels, these activators inherently influence the activity of C11orf20. Alterations in cellular ion balance brought about by this chemical class can result in changes to the CATSPER channel function. The precise mechanisms by which these activators influence C11orf20 are complex and rely on a network of cellular signals and ion channel interactions, underscoring the intricate nature of sperm physiology and the delicate regulation of sperm motility and function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

8-Bromoadenosine 3′,5′-cyclic monophosphate

23583-48-4sc-217493B
sc-217493
sc-217493A
sc-217493C
sc-217493D
25 mg
50 mg
100 mg
250 mg
500 mg
$108.00
$169.00
$295.00
$561.00
$835.00
2
(1)

A cAMP analog that activates PKA and may increase CATSPER channel activity, involving C11orf20.

Progesterone

57-83-0sc-296138A
sc-296138
sc-296138B
1 g
5 g
50 g
$20.00
$52.00
$298.00
3
(1)

A steroid hormone known to modulate CATSPER channel activity, which may involve C11orf20.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

Influences sperm capacitation and may affect CATSPER channel function, thus C11orf20.

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$63.00
$182.00
8
(1)

Modulates calcium signaling pathways, which may affect C11orf20.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

A tyrosine kinase inhibitor that modulates signal transduction pathways related to C11orf20.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$96.00
$160.00
$240.00
$405.00
26
(1)

Activates TRPV channels, leading to calcium influx that may enhance CATSPER activity and C11orf20.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$33.00
$67.00
$97.00
$192.00
$775.00
13
(1)

Blocks phosphodiesterases, increasing cAMP, which may modulate C11orf20 channel activity.

Tadalafil

171596-29-5sc-208412
50 mg
$180.00
13
(2)

Alters cGMP levels, which may influence CATSPER channel activity and C11orf20.

Niflumic acid

4394-00-7sc-204820
5 g
$32.00
3
(1)

Blocks certain chloride channels, affecting cellular ion balance and may impact CATSPER channel function and C11orf20.