C10orf93 Inhibitors
C10orf93 inhibitors encompass a range of chemical compounds that exert their effects through interference with microtubule dynamics, a critical aspect of ciliary structure and function to which C10orf93 is fundamentally linked. Lithium chloride, for example, inhibits GSK-3, a kinase involved in microtubule organization, potentially leading to ciliary dysfunctions that could impair C10orf93's activity. Similarly, agents that target microtubule polymerization, such as nocodazole, colchicine, demecolcine, podophyllotoxin, vinblastine, and vincristine, disrupt the structural integrity of microtubules, which constitute the ciliary skeleton. By destabilizing these structures, these compounds can indirectly inhibit the function of C10orf93, given its associationwith cilia. Paclitaxel, in contrast, stabilizes microtubules, which also perturbs the normal dynamic state necessary for ciliary function and could thus hinder C10orf93's role in this context.
On the other hand, chemicals like chloral hydrate, though its direct mechanism on C10orf93 is not explicit, may influence the expression or functionality of ciliary proteins, thereby indirectly leading to C10orf93 inhibition. Griseofulvin and monastrol, by disrupting microtubule function and spindle formation, respectively, affect processes that are crucial for proper ciliary assembly and function, suggesting a potential indirect reduction in C10orf93 activity. Ouabain's inhibition of the Na+/K+-ATPase pump alters ionic balances that are essential for maintaining ciliary beat frequency, which can indirectly affect C10orf93, a protein whose function is entwined with the ciliary apparatus. Collectively, these inhibitors highlight the intricate dependencies within cellular structures and processes that C10orf93 relies upon, and their modulation provides insights into the indirect regulatory mechanisms that can influence the functional activity of C10orf93.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a glycogen synthase kinase 3 (GSK-3) inhibitor. Since GSK-3 is involved in microtubule dynamics, which is crucial for ciliogenesis, lithium chloride's inhibition of GSK-3 can indirectly result in the abnormal function of C10orf93, which is associated with ciliary structure and function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, thereby affecting microtubule dynamics. C10orf93, being linked to ciliary structure, relies on intact microtubules for its proper function, so nocodazole, by depolymerizing microtubules, could lead to the functional inhibition of C10orf93. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, essential structures for ciliogenesis. As C10orf93 is involved with ciliary function, colchicine-mediated disruption of microtubules can indirectly inhibit C10orf93's activity as part of the ciliary structure. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, which can disrupt normal microtubule dynamics. C10orf93 function may be compromised as its normal biological context within cilia is dependent on proper microtubule turnover and dynamics. | ||||||
Trichloroacetaldehyde-13C2 | sc-474862 | 2.5 mg | $380.00 | |||
Chloral hydrate can act as a sedative and hypnotic that affects the central nervous system. While its direct impact on C10orf93 is unclear, it could potentially affect the expression or function of proteins involved in ciliary function and thus indirectly inhibit C10orf93. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $68.00 $162.00 $318.00 $947.00 $1893.00 $6840.00 | 7 | |
Demecolcine inhibits microtubule polymerization, which is an essential process for ciliogenesis. An inhibitor of this process can therefore indirectly disrupt the function of C10orf93 due to its association with ciliary structures. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin is an inhibitor of microtubule assembly, which would affect ciliogenesis. The functional activity of C10orf93, being implicated in ciliary biology, would likely be inhibited by disruptions in microtubule formation caused by podophyllotoxin. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting tubulin polymerization into microtubules. Since C10orf93 is associated with the ciliary apparatus, which relies on microtubules, the inhibition of microtubule assembly could indirectly impair C10orf93's function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, which can affect cell division and could indirectly inhibit C10orf93 activity due to its role in the structurally important ciliary apparatus. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts spindle formation during mitosis. Its effect on microtubule-dependent processes could indirectly inhibit C10orf93, which is implicated in the formation and function of cilia. | ||||||