C10orf63 Inhibitors
Enkurin, TRPC channel interacting protein, known by its gene name ENKUR, is a relatively less characterized protein that interacts with members of the transient receptor potential canonical (TRPC) family of ion channels. TRPC channels are involved in various physiological processes, including the regulation of calcium influx into the cell following activation by a wide array of stimuli.Enkurin is believed to modulate the activity of TRPC channels, thereby influencing intracellular calcium signaling cascades that are critical for cellular functions such as growth, differentiation, and apoptosis. The precise molecular mechanisms by which enkurin interacts with these channels are still under investigation, but it is hypothesized that enkurin may serve as a scaffolding protein, playing a role in the stabilization of channel complexes at the cell membrane or in intracellular signaling domains.
The protein contains several domains that are suggestive of its role in protein-protein interactions, including a coiled-coil domain that is typical for proteins involved in forming complexes with other proteins. Such interactions are crucial for the assembly and regulation of multiprotein signaling complexes that can rapidly respond to changes in the cellular environment.Given its potential regulatory role in calcium signaling, enkurin may have implications for a wide range of cellular processes and diseases where calcium homeostasis and signaling are disrupted. Dysregulation of TRPC channel activity, for instance, has been associated with cardiovascular diseases, neurodegenerative disorders, and cancer. Therefore, understanding the role of enkurin in modulating TRPC channels could provide insights into novel targets for such conditions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
Inhibits TRPC channels, potentially altering calcium influx influenced by enkurin-TRPC interaction. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Modulates TRPC channels, affecting calcium signaling pathways associated with enkurin. | ||||||
PT 1 | 331002-70-1 | sc-361299 sc-361299A | 10 mg 50 mg | $185.00 $781.00 | 1 | |
Potent and selective inhibitor of TRPC4 and TRPC5 channels, potentially affecting enkurin's regulatory functions. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Non-selective inhibitor of TRPC channels, which may influence enkurin's interaction with these channels. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $88.00 | ||
Blocks calcium channels including TRPC channels, potentially altering enkurin-mediated activities. | ||||||
SAR7334 | 1333210-07-3 | sc-507445 | 10 mg | $510.00 | ||
Highly selective TRPC6 inhibitor, could indirectly affect enkurin's regulation of TRPC channel activity. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $185.00 | 9 | |
Inhibits several TRPC channels, potentially affecting enkurin's regulatory role. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Antifungal agent known to inhibit TRPC channels, potentially affecting enkurin's functions. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
Non-steroidal anti-inflammatory drug (NSAID) that modulates TRPC channels, potentially influencing enkurin interaction. | ||||||