c-Src Inhibitors

1-Naphthyl PP1 (CAS 221243-82-9) is a chemical compound known for its role as a c-Src inhibitor. By targeting the ATP-binding site of c-Src, it effectively modulates the protein's activity, thereby influencing essential cellular processes necessary for normal cellular function.

PKC-412 (CAS 120685-11-2) is a chemical compound with notable c-Src inhibitory properties. By engaging with the ATP-binding site of c-Src, it effectively regulates the protein's activity, impacting various fundamental cellular processes essential for normal cell operation.

PP1 is a synthetic inhibitor that specifically targets c-src and other Src-family kinases. It has been used in laboratory studies to investigate the roles of these kinases in various cellular processes.

PDGFR Tyrosine Kinase Inhibitor IV exhibits a unique mechanism of action by selectively targeting c-Src, a key player in various signaling pathways. It disrupts the phosphorylation of specific tyrosine residues, thereby modulating downstream signaling cascades involved in cell growth and migration. The compound's kinetic profile reveals a rapid binding affinity, influencing cellular dynamics and altering the balance of kinase activity. Its distinct interactions with protein substrates underscore its role in regulating cellular responses.

TX-1123 (CAS 157397-06-3) is a chemical compound recognized for its ability to inhibit c-Src. By interacting with the ATP-binding site of c-Src, it modulates the protein's activity, impacting various cellular processes essential for normal cell function.

PD-180970 is a selective inhibitor of c-Src that operates through intricate molecular interactions, particularly by stabilizing the inactive conformation of the kinase. This compound exhibits a unique ability to disrupt the ATP-binding site, leading to altered reaction kinetics and reduced enzymatic activity. Its specificity for c-Src allows for precise modulation of cellular signaling pathways, influencing processes such as cytoskeletal organization and cell adhesion. The compound's distinct binding dynamics contribute to its regulatory effects on cellular behavior.

PD173955 is a small molecule inhibitor that primarily targets c-src kinase. It has been used to investigate c-src's role in cell migration and invasion.

Neratinib (CAS 698387-09-6) is a chemical compound known for its capacity to inhibit c-Src. By targeting the ATP-binding site of c-Src, it effectively modulates the protein's activity, influencing crucial cellular processes necessary for normal cell function.

AGL 2263 functions as a selective c-Src inhibitor, characterized by its unique binding affinity that promotes a conformational shift in the kinase. This compound effectively interferes with the phosphorylation cascade by targeting specific residues within the active site, thereby modulating downstream signaling pathways. Its distinct interaction profile enhances selectivity, allowing for nuanced control over cellular processes such as migration and proliferation, while influencing the overall dynamics of protein-protein interactions.

Altenusin acts as a selective modulator of c-Src activity, exhibiting a unique mechanism of action through its ability to stabilize an inactive conformation of the kinase. This compound disrupts the ATP-binding site, leading to altered reaction kinetics and reduced catalytic efficiency. Its specific interactions with key amino acid residues facilitate a shift in the enzyme's conformational landscape, ultimately impacting cellular signaling networks and influencing the balance of phosphorylation events.