AGL 2263
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AGL 2263 is a cell-permeable benzoxazolone-containing bioisostere of tyrphostin AG 538 that acts as a potent, substrate-competitive, but not ATP-competitive, inhibitor of IR (insulin receptor) and IGF-IR (insulin-like growth factor-1 receptor). AGL 2263 is selective towards IR and IGF-IR (IC50 = 0.4 and 0.43 muM, respectively) and inhibits c-Src (Src) and Akt (PKB) at much higher concentrations (IC50 = 2.2 and 55 muM, respectively) in kinase assays. AGL 2263 may act to prevent IGF-1-induced cellular IGF-IR autophosphorylation and down stream signalling. Specifically inhibits IGF-1-induced, but not PDGF-induced, activation of Akt (PKB) in cells. AGL 2263 effectively blocks the formation of colonies in soft agar by breast and prostate cancer cells. Exhibits improved cellular oxidative stability than AG 538.
AGL 2263 References
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- JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. | Nishiya, N., et al. 2015. World J Biol Chem. 6: 409-18. PMID: 26629323
- Procyanidin B1 and p-Coumaric Acid from Highland Barley Grain Showed Synergistic Effect on Modulating Glucose Metabolism via IRS-1/PI3K/Akt Pathway. | Liu, ZH. and Li, B. 2021. Mol Nutr Food Res. 65: e2100454. PMID: 34342938
- Chlorogenic acid and β-glucan from highland barley grain ameliorate β-cell dysfunction via inhibiting apoptosis and improving cell proliferation. | Liu, ZH. and Li, B. 2021. Food Funct. 12: 10040-10052. PMID: 34515712
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AGL 2263, 5 mg | sc-221223 | 5 mg | $357.00 |