c-Fos Activators
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132, a selective proteasome inhibitor, disrupts protein degradation pathways by binding to the active site of the proteasome. This compound exhibits a unique ability to stabilize polyubiquitinated proteins, leading to the accumulation of regulatory factors that influence gene expression. Its kinetic profile reveals rapid binding and prolonged effects on cellular signaling, particularly in modulating transcription factors like c-Fos, thereby impacting various cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates c-Fos by stimulating protein kinase C (PKC), which in turn phosphorylates c-Fos. This phosphorylation enhances c-Fos's transcriptional activity, leading to increased gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates c-Fos through adenylyl cyclase stimulation, resulting in increased levels of cyclic AMP (cAMP). Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates c-Fos, enhancing its transcriptional activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates c-Fos by inhibiting protein synthesis at the ribosome level. This leads to the activation of stress-responsive kinases, such as JNK, which phosphorylate and activate c-Fos, inducing its transcriptional activity. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $107.00 $362.00 | 2 | |
NMDA activates c-Fos by stimulating glutamate receptors in neurons. This triggers calcium influx, which activates various kinases and transcription factors, including c-Fos, resulting in increased c-Fos expression. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A activates c-Fos by inhibiting protein phosphatases, particularly protein phosphatase 1 (PP1). This inhibition leads to sustained phosphorylation of c-Fos and enhances its transcriptional activity. | ||||||
Kainic acid monohydrate | 58002-62-3 | sc-269283 | 10 mg | $270.00 | ||
Kainic Acid activates c-Fos by binding to kainate receptors, which leads to calcium influx and the activation of kinases and transcription factors, including c-Fos. This results in increased c-Fos expression and transcriptional activity. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
This compound, similar to PMA, activates c-Fos through PKC stimulation, leading to c-Fos phosphorylation and enhanced transcriptional activity, ultimately promoting gene expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin activates c-Fos by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, leading to calcium release from intracellular stores. Increased calcium levels activate kinases, including those that phosphorylate c-Fos. | ||||||