BUD13 Activators
The class of chemicals referred to as BUD13 Activators encompasses compounds that have the to indirectly influence the function of the BUD13 protein within the context of pre-mRNA splicing regulation. BUD13, an integral component of the spliceosome, plays a pivotal role in splicing by facilitating the recognition of splice sites within pre-mRNA transcripts. While specific chemical activators for BUD13 are not established, theoretical suggestions include compounds like Resveratrol and Curcumin, known for their effects on signaling pathways such as SIRT1 and NF-κB, respectively. These chemicals can indirectly impact gene expression and splicing, contributing to the activation of BUD13 within the spliceosome.
Quercetin and Sodium Butyrate are also considered as BUD13 activators. Quercetin's influence on the PI3K/AKT pathway and Sodium Butyrate's modulation of histone acetylation are pathways that can indirectly affect splicing processes, offering a theoretical mechanism for BUD13 activation. Additionally, histone deacetylase (HDAC) like Vorinostat (SAHA) can modulate gene expression and splicing, indirectly contributing to the activation of BUD13. These chemicals represent a theoretical class of activators that may influence splicing-related pathways and processes, indirectly affecting BUD13's role in pre-mRNA splicing regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can influence the SIRT1 pathway, which may indirectly affect splicing regulation, potentially contributing to BUD13 activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been associated with modulating the NF-κB pathway, which can influence gene expression and splicing, indirectly activating BUD13. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can affect the PI3K/AKT pathway, potentially impacting splicing processes and indirectly contributing to BUD13 activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is known to influence histone acetylation, which can affect chromatin structure and splicing, indirectly activating BUD13. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a histone deacetylase (HDAC) inhibitor, which can modulate gene expression and splicing, potentially indirectly activating BUD13. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone can influence glucocorticoid receptor signaling, which may indirectly impact splicing processes and activate BUD13. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been linked to the inhibition of the Wnt pathway, which can indirectly affect splicing regulation and potentially activate BUD13. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can activate the Nrf2 pathway, influencing gene expression and splicing, indirectly contributing to BUD13 activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Sodium Valproate can influence histone acetylation and may indirectly affect chromatin structure, potentially activating BUD13. | ||||||