BTN2A2 Inhibitors
BTN2A2 inhibitors are a class of chemical compounds designed to target and modulate the activity of the BTN2A2 protein. BTN2A2, or Butyrophilin Subfamily 2 Member A2, is part of the butyrophilin family, which belongs to the immunoglobulin superfamily. BTN2A2 plays a significant role in various cellular processes, including immune modulation and protein-protein interactions. It is a membrane-bound protein involved in signaling pathways that influence cell-to-cell communication, particularly within the immune system. Inhibitors of BTN2A2 are specifically designed to interfere with its ability to interact with other proteins or cellular components, thus modulating the signaling pathways it regulates.
The design of BTN2A2 inhibitors involves targeting the extracellular domain of the protein, where it interacts with other receptors or ligands. These inhibitors are often engineered to bind with high affinity to the active or binding sites of BTN2A2, effectively blocking its normal function. Structural biology and computational modeling are key tools used in identifying suitable binding sites and optimizing the interaction between the inhibitor and BTN2A2. The inhibitors are designed to be selective, ensuring they disrupt BTN2A2 activity without affecting similar proteins in the butyrophilin family. By inhibiting BTN2A2, these compounds are valuable in research for understanding the protein's role in immune regulation and signaling. Through the use of BTN2A2 inhibitors, researchers can explore the protein's function and its broader impact on cellular processes, offering insight into the regulatory mechanisms BTN2A2 governs in various biological pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
This chemical is a potent and specific inhibitor of protein kinase C (PKC), a family of enzymes that phosphorylate BTN2A2, leading to its activation. By inhibiting PKC, Bisindolylmaleimide I prevents the phosphorylation and subsequent activation of BTN2A2. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a pan-PKC inhibitor, known to inhibit multiple isoforms of PKC which are involved in the phosphorylation of proteins including BTN2A2. The inhibition of PKC by Go 6983 thus hinders the phosphorylation-dependent functional activation of BTN2A2. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro 31-8220 acts as a PKC inhibitor with broad specificity. It inhibits PKC-mediated phosphorylation processes, which are essential for BTN2A2 activation. By hindering these processes, Ro 31-8220 functionally inhibits BTN2A2. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin is known to selectively inhibit PKC, particularly targeting the isoforms that phosphorylate BTN2A2. By preventing PKC from phosphorylating BTN2A2, Sotrastaurin inhibits the protein's function. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $259.00 $612.00 $1721.00 | 3 | |
Enzastaurin is a selective inhibitor of PKCβ, which is involved in the phosphorylation and regulation of BTN2A2. By specifically inhibiting PKCβ, Enzastaurin prevents the functional activation of BTN2A2 through phosphorylation. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
Ruboxistaurin selectively inhibits PKCβ, thereby impeding the phosphorylation process that would otherwise activate BTN2A2. This chemical's action directly inhibits BTN2A2's function by preventing its activation through phosphorylation. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a PKC inhibitor that would prevent the phosphorylation of BTN2A2, thereby inhibiting its function. While Chelerythrine is a broad inhibitor, its action on the PKC isoforms that regulate BTN2A2 leads to the functional inhibition of the protein. | ||||||
Hispidin | 555-55-5 | sc-203998 | 5 mg | $416.00 | ||
Hispidin is an inhibitor of PKC, and by extension, it inhibits the function of BTN2A2 by preventing its phosphorylation and activation. Targeting the PKC-mediated signaling pathway, Hispidin specifically inhibits the functional activation of BTN2A2. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases, including PKC. By broadly inhibiting protein kinases, Staurosporine can prevent the phosphorylation of BTN2A2, thereby functionally inhibiting the protein. | ||||||
Balanol | 63590-19-2 | sc-503251 | 10 mg | $13500.00 | ||
Balanol is an inhibitor of protein kinase C, which would prevent the phosphorylation and activation of BTN2A2. By inhibiting this pathway, Balanol functionally inhibits the activity of BTN2A2. | ||||||