Molecular structure of Hispidin, CAS Number: 555-55-5
Hispidin (CAS 555-55-5)
Alternate Names:
6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone
Application:
Hispidin is a cell permeable inhibitor of PKCβ
CAS Number:
555-55-5
Purity:
98%
Molecular Weight:
246.2
Molecular Formula:
C13H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Hispidin is a polyketide compound studied primarily for its role as a natural antioxidant found in certain species of fungi, including those from the genus Phellinus. Research on Hispidin focuses on its ability to scavenge free radicals, which is essential in understanding the mechanisms of oxidative stress in biological systems. In biochemical studies, Hispidin serves as a substrate for the enzyme laccase, which catalyzes its oxidation to various oligomeric compounds, shedding light on fungal pigment biosynthesis. Additionally, it is utilized in the exploration of bioluminescence, as Hispidin is a precursor to luciferin in some bioluminescent fungi. Studies involving Hispidin also delve into its interaction with proteins and enzymes, aiding in the elucidation of signaling pathways and cellular defense mechanisms.
Hispidin (CAS 555-55-5) References
- Hispidin isolated from Phellinus linteus protects against hydrogen peroxide-induced oxidative stress in pancreatic MIN6N β-cells. | Lee, JH., et al. 2011. J Med Food. 14: 1431-8. PMID: 22003875
- Hispidin produced from Phellinus linteus protects against peroxynitrite-mediated DNA damage and hydroxyl radical generation. | Chen, W., et al. 2012. Chem Biol Interact. 199: 137-42. PMID: 22819952
- Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells. | Lim, JH., et al. 2014. Anticancer Res. 34: 4087-93. PMID: 25075033
- Anti-obesity effects of hispidin and Alpinia zerumbet bioactives in 3T3-L1 adipocytes. | Tu, PT. and Tawata, S. 2014. Molecules. 19: 16656-71. PMID: 25322285
- Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-κB activation. | Shao, HJ., et al. 2015. J Sci Food Agric. 95: 2482-6. PMID: 25355452
- Cytoprotective effect of hispidin against palmitate-induced lipotoxicity in C2C12 myotubes. | Park, JM., et al. 2015. Molecules. 20: 5456-67. PMID: 25826786
- Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization. | Lv, LX., et al. 2017. Oncotarget. 8: 26992-27006. PMID: 28460485
- Hispidin rescues palmitate‑induced insulin resistance in C2C12 myotubes. | Lee, JS., et al. 2017. Mol Med Rep. 16: 4229-4234. PMID: 28731188
- Combination Effects of Hispidin and Gemcitabine via Inhibition of Stemness in Pancreatic Cancer Stem Cells. | Chandimali, N., et al. 2018. Anticancer Res. 38: 3967-3975. PMID: 29970519
- The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway. | Huang, SY., et al. 2019. Biomolecules. 9: PMID: 31430968
- Screening for proteins related to the biosynthesis of hispidin and its derivatives in Phellinus igniarius using iTRAQ proteomic analysis. | Guo, J., et al. 2021. BMC Microbiol. 21: 81. PMID: 33711926
- Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling. | Jin, MH., et al. 2021. Exp Ther Med. 22: 970. PMID: 34335912
- Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro Model of Parkinson's Disease. | Lai, MC., et al. 2023. Nutrients. 15: PMID: 36771255
- Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells. | Wu, F., et al. 2023. Evid Based Complement Alternat Med. 2023: 9428241. PMID: 36865751
- Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro. | Gonindard, C., et al. 1997. Cell Biol Toxicol. 13: 141-53. PMID: 9088624
Inhibitor of:
ARH2, BTN2A2, CIB4, cPKC βI, GRK 7, HNRPLL, IQCD, LCE1B, LIN-7, LRFN1, LYPD6, MARCKS, OTTMUSG00000010173, Pbx2, Pcdhb20, PKC ζII, PKC beta, PREP-2, PRK1, Ser/Thr Protein Kinase, TM4SF18, ZFP105, ZIP, and ZNF10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hispidin, 5 mg | sc-203998 | 5 mg | $416.00 |