BGT-1 Activators
BGT-1 Activators, as a chemical class, represent a diverse group of compounds that can influence the function of the BGT-1 protein, also known as SLC6A12. This protein is a betaine/GABA transporter that also transports Cl- ions and is known to be sensitive to changes in ion gradients and concentrations. BGT-1, or betaine-gamma-aminobutyric acid (GABA) transporter 1, is a protein that plays a crucial role in the cellular process of osmoregulation and neurotransmission. It functions by actively transporting betaine and GABA across cell membranes, thereby regulating cell volume and neuronal excitability.
Direct activators of BGT-1 can interact with the transporter at the molecular level, by binding to its allosteric sites or transmembrane domains, leading to a change in the transporter's conformation that results in increased affinity or transport rate for its substrates. This can involve stabilizing the protein structure in a conformation that favors substrate binding or facilitating the transition between different states of the transport cycle more efficiently. Indirect activators, on the other hand, might not interact with BGT-1 directly but can affect its function through modulation of associated cellular pathways. These can include compounds that increase the expression level of BGT-1 by acting on transcription factors or on the epigenetic machinery that controls the gene's accessibility. Chemicals that inhibit the degradation pathways or proteosomal turnover of BGT-1 can also serve as indirect activators by increasing the amount of functional transporter available in the cell membrane. Additionally, indirect activators might influence the cellular localization of BGT-1, ensuring that it is correctly inserted into the membrane where it can perform its transport function. This can involve the modulation of chaperone proteins or the cellular trafficking machinery that conveys BGT-1 to the membrane.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid is a nonsteroidal anti-inflammatory drug that acts as a Cl- channel blocker. By inhibiting certain Cl- channels, it can potentially affect the function of BGT-1 (SLC6A12), a betaine/GABA transporter that also transports Cl- ions. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker. By modulating calcium influx into the cell, it can influence intracellular signaling pathways that may affect the regulation of BGT-1, which is known to be calcium-sensitive. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a nonspecific adenosine receptor antagonist. Through this action, it can modulate the intracellular cAMP levels, that can in turn affect the regulation of BGT-1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a direct activator of adenylate cyclase, leading to increased cAMP levels. Higher cAMP levels can affect the regulation of BGT-1 by modulating its phosphorylation state and potentially increasing its activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate provides zinc ions, which can modulate the activity of BGT-1 by binding to its zinc-binding site and influencing its conformation and function. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a specific inhibitor of the Na+/K+ ATPase. By modulating the Na+ and K+ gradients across the cell membrane, it can indirectly affect the function of BGT-1, which relies on these gradients for its transport function. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1, a Ca2+ channel. By affecting calcium influx into the cell, it can influence intracellular signaling pathways that regulate BGT-1. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $47.00 $100.00 | 1 | |
Taurine is an organic acid that has been shown to modulate Cl- and GABA transport. It can potentially affect the function of BGT-1, which also transports Cl- ions and GABA. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline is a nonspecific phosphodiesterase inhibitor. By inhibiting these enzymes, it can increase cAMP levels, which can in turn affect the regulation of BGT-1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a broad-spectrum tyrosine kinase inhibitor. By inhibiting tyrosine kinases, it can affect intracellular signaling pathways that regulate the phosphorylation state of BGT-1, potentially modulating its function. | ||||||