BC094916 Activators
Ifi214, known as Interferon Activated Gene 214, encodes a protein belonging to the PAAD/DAPIN/Pyrin domain family. This protein is unique in that it is C-terminally truncated and lacks a HIN domain, which is present in related proteins like Pyrin and HIN domain family member 1 (Pyhin1). The precise function of Ifi214 is not fully understood, and its potential role as a pseudogene of Pyhin1 suggests a complex regulatory landscape. Despite the absence of a HIN domain, the intact PAAD/DAPIN/Pyrin domain suggests a functional role, possibly involving protein-protein interactions or signal transduction. Activation mechanisms of Ifi214 remain elusive, given its distinctive structure and the lack of a well-defined functional domain. The activation of Ifi214 could be influenced by interferon signaling pathways, given its nomenclature as an interferon-activated gene. Interferons are key players in the immune response, particularly against viral infections. Therefore, it is conceivable that Ifi214 might play a role in antiviral defense or immune regulation. However, the exact signaling cascades and cellular processes that directly activate Ifi214 remain to be elucidated.
Moreover, the potential involvement of Ifi214 in regulatory pathways beyond interferon signaling cannot be ruled out. It may interact with various cellular components or participate in specific cellular processes, contributing to its activation. Investigating the specific molecular partners, if any, that bind to the PAAD/DAPIN/Pyrin domain of Ifi214 may provide insights into its functional role and activation mechanisms. Understanding the nuanced interactions and regulatory circuits involving Ifi214 is crucial for unraveling its contributions to cellular homeostasis and immune responses, potentially shedding light on its role in health and disease. Further experimental studies are warranted to delineate the precise molecular events leading to the activation of Ifi214 and to elucidate its functional significance in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor potentially influencing Ifi214. 5-Azacytidine may indirectly modulate Ifi214 by inhibiting DNA methylation, impacting gene expression patterns. This modulation can affect Ifi214 activity and its involvement in cellular processes. Exploring the connections between DNA methylation inhibition and Ifi214 sheds light on the epigenetic regulation of the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor potentially impacting Ifi214 activation. SB203580 may indirectly modulate Ifi214 by inhibiting the p38 MAPK pathway. This inhibition can alter the phosphorylation status of molecules influencing Ifi214 activity. Investigating the cross-talk between p38 MAPK signaling and Ifi214 sheds light on the regulatory mechanisms governing the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase (HDAC) inhibitor potentially affecting Ifi214. Trichostatin A may indirectly activate Ifi214 by inhibiting HDACs, leading to altered acetylation patterns on histones and potentially affecting Ifi214 expression or activity. Investigating the impact of HDAC inhibition on Ifi214 sheds light on the epigenetic regulation of the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor influencing Ifi214 activation. PD98059 may indirectly modulate Ifi214 by inhibiting MEK, impacting downstream signaling pathways. This inhibition can alter Ifi214 activity and its participation in cellular processes. Investigating the connections between MEK inhibition and Ifi214 sheds light on the regulatory mechanisms governing the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMP-activated protein kinase (AMPK) activator influencing Ifi214. AICAR may directly or indirectly activate Ifi214 by modulating AMPK activity. The activation of AMPK can impact Ifi214 through various cellular processes, potentially regulating its function. Unraveling the connections between AMPK activation and Ifi214 sheds light on the regulatory mechanisms governing the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
NF-κB inhibitor potentially influencing Ifi214 activation. JSH-23 may indirectly modulate Ifi214 by inhibiting NF-κB signaling, influencing downstream pathways. This inhibition can alter Ifi214 activity and its involvement in cellular processes. Investigating the connections between NF-κB inhibition and Ifi214 sheds light on the regulatory mechanisms governing the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
EZH2 inhibitor potentially affecting Ifi214 activation. GSK343 may indirectly modulate Ifi214 by inhibiting EZH2, impacting epigenetic regulation. This inhibition can alter Ifi214 activity and its participation in cellular processes. Investigating the connections between EZH2 inhibition and Ifi214 sheds light on the epigenetic control over the PAAD/DAPIN/Pyrin domain family of proteins. | ||||||