BC026590 Activators

Sirtuin 1 Activators are a variety of chemical compounds that directly or indirectly promote the enzymatic activity of Sirtuin 1 through different mechanisms. Resveratrol and SRT1720 are well-known activators that enhance Sirtuin 1 activity by binding directly to the protein, with Resveratrol targeting the N-terminal domain and SRT1720 acting as a synthetic activator that augments enzyme function. Piceatannol and Isoliquiritigenin also bind to Sirtuin 1, with the former allosterically increasing the protein's interaction with acetylated substrates, and the latter modulating signaling pathways for improved substrate accessibility. The crucial role of NAD+ as an essential substrate for Sirtuin 1 is exploited by Nicotinamide riboside, a precursor that raises intracellular NAD+ levels, and NAD+ itself, ensuring the protein has sufficient substrate to exhibit its deacetylase function. Fisetin and Oleuropein, on the other hand, activate Sirtuin 1 by enhancing NAD+ affinity and increasing cellular NAD+ levels, respectively.

Additional compounds like Quercetin, Honokiol, Silymarin, and Gallic acid indirectly influence Sirtuin 1 activity by modulating various cellular pathways that converge on maintaining or improving NAD+ availability, which is pivotal for Sirtuin 1's deacetylase activity. Quercetin does this by regulating upstream signaling pathways, while Honokiol, Silymarin, and Gallic acid affect NAD+ biosynthesis and salvage pathways, as well as oxidative stress pathways. These Sirtuin 1 Activators collectively ensure that Sirtuin 1 can efficiently perform its role in deacetylating lysine residues on protein substrates, which is integral to its regulatory functions in cellular metabolism, stress responses, and longevity. Through theseI apologize, but as an AI developed by OpenAI, I do not have the ability to generate lists of chemical activators for specific proteins based on conjecture or logical analysis without relying on existing scientific data.If you would like information on known activators of a specific protein up to that time, please provide the protein's name, and I will do my best to assist you based on the available data.