BC024814 Activators
mTOR Activators are a collection of chemical compounds that facilitate the activation of mTOR signaling pathways, which regulate key cellular processes such as growth, proliferation, and metabolism. Rapamycin, despite being a well-known inhibitor of mTORC1, paradoxically can increase the activity of mTORC2 by disrupting a negative feedback loop, thus enhancing mTORC2's specific functions. Insulin, through the PI3K/AKT pathway, phosphorylates and inhibits the TSC2, unleashing mTORC1 activity which is pivotal in cell growth and protein synthesis. BC024814 activators are a specialized group of compounds that are characterized by their ability to enhance the activity of the molecular target identified by the code BC024814. The discovery and development of these activators typically commence with a high-throughput screening (HTS) protocol.
This involves the application of large libraries of chemical entities to an assay system designed to detect the activation of BC024814. These assays are sensitive and quantitative, often relying on fluorescent or luminescent readouts that can directly correlate with the activation state of BC024814. Compounds that produce a measurable increase in the activity of BC024814 are singled out as potential activators and earmarked for further scrutiny. The ensuing step involves secondary assays, which are more focused and provide a deeper evaluation of the compound's specific interaction with BC024814. These assays are crucial in establishing the validity of the HTS hits, ensuring that these compounds are genuine activators and not false positives that could arise from nonspecific interactions or assay artifacts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that binds to FKBP12 and then to mTORC1, leading to inhibition of mTORC1-dependent signaling. This inhibition can indirectly enhance mTORC2 activity by relieving a feedback inhibition loop, thereby potentially increasing mTORC2 signaling functions. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/AKT signaling pathway, which in turn activates mTOR by phosphorylating and inhibiting TSC2, a negative regulator of mTORC1. This process enhances the functional activity of mTORC1 involved in cell growth, protein synthesis, and metabolism. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
PA directly binds to the FRB domain of mTOR and stabilizes mTORC1 complex formation. This binding enhances mTORC1 kinase activity, promoting its downstream effects on protein synthesis and cell growth. | ||||||
MHY1485 | 326914-06-1 | sc-507522 | 10 mg | $140.00 | ||
MHY1485 is a cell-permeable mTOR activator that directly binds to mTOR and enhances its kinase activity. By activating mTOR, MHY1485 promotes downstream signaling pathways that control cell growth and metabolism. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose availability promotes mTORC1 signaling through the AMPK and TSC2 pathway. With sufficient glucose, mTORC1 is activated, leading to increased protein synthesis and cell growth. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
Leucine is an essential amino acid that activates mTORC1 by binding to sestrin2 or the leucyl-tRNA synthetase, leading to inhibition of the GATOR2 complex which is a negative regulator of the mTOR pathway. Thereby, it enhances mTORC1 activity involved in protein synthesis. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been shown to activate mTORC1 by promoting the translation of its components via the hypusination of eIF5A, which is necessary for the synthesis of polyamines. This activation of mTORC1 stimulates protein synthesis and cell growth. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can indirectly activate mTORC1 by inhibiting AMPK, an upstream kinase that negatively regulates mTORC1. Inhibition of AMPK by resveratrol leads to reduced TSC2 activity, thereby enhancing mTORC1 activity in energy metabolism and cell growth. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
LPA activates the mTOR pathway through G protein-coupled receptors (GPCRs) and the PI3K/AKT pathway. This activation leads to mTORC1 activation and its downstream effects on cell growth and survival. | ||||||