BBS8 Activators
BBS8 activators is a term that generally refers to chemicals that can indirectly influence the function of the BBS8 protein. These chemicals often exert their effects by modulating different cellular processes associated with cilia formation and function, a key role of BBS8. Chemicals such as retinoic acid and forskolin can enhance ciliogenesis, and through this process, indirectly influence BBS8 function. Similarly, IBMX, by increasing cellular cAMP levels, and ionomycin, by raising intracellular calcium levels, can also impact cilia formation and thus indirectly influence BBS8.
On the other hand, some chemicals like cytochalasin D, colchicine, vinblastine, and nocodazole disrupt the cellular architecture necessary for cilia formation, thereby indirectly affecting BBS8. These chemicals modulate the structure and function of actin filaments and microtubules, critical components of the cell's cytoskeleton and essential for cilia formation. Lastly, chemicals like paclitaxel and Taxol stabilize microtubules, and zoledronic acid, by influencing osteoblasts which contain primary cilia, can indirectly influence BBS8. The variance in the mechanisms of these chemicals illustrates the diverse cellular processes that can indirectly influence BBS8 function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can enhance ciliogenesis, which indirectly influences BBS8 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can stimulate Wnt signaling pathway, indirectly influencing cilia-associated proteins like BBS8. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can stimulate cAMP production, which is essential for cilia formation and function, thereby indirectly influencing BBS8. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX increases cellular cAMP levels, indirectly influencing cilia-associated proteins like BBS8. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin can increase intracellular calcium levels, which can impact cilia formation and indirectly influence BBS8. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D can disrupt actin filaments and indirectly influence cilia formation, thereby impacting BBS8. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine can inhibit microtubule assembly, indirectly influencing cilia formation and BBS8. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole can disrupt microtubules and indirectly affect cilia formation and BBS8. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, indirectly influencing cilia formation and BBS8. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic acid can influence osteoblasts which contain primary cilia, thereby indirectly influencing BBS8. | ||||||