BBS8 Antibody (E-2): sc-271009

BBS8 Antibody (E-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects BBS8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BBS8 Antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BBS8, also known as tetratricopeptide repeat protein (TTC8), plays a crucial role in the function of cilia, which are essential for various cellular processes, including signaling pathways and cellular homeostasis maintenance. Dysfunction in ciliary proteins, such as BBS8, is implicated in Bardet-Biedl syndrome (BBS), a complex genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, and renal abnormalities. BBS8 contributes to the structural integrity and function of cilia, which are vital for proper cellular communication and movement. Mutations in BBS8 account for a small percentage of BBS cases, highlighting the genetic heterogeneity of the disorder and the challenges in understanding its pathogenesis. Anti-BBS8 antibody (E-2) facilitates research into the molecular mechanisms underlying BBS and the role of ciliary dysfunction in various diseases.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

BBS8 Antibody (E-2) References:

1. Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins.  |  Cortajarena, AL., et al. 2004. Protein Eng Des Sel. 17: 399-409. PMID: 15166314
2. Ocular phenotypes of three genetic variants of Bardet-Biedl syndrome.  |  Héon, E., et al. 2005. Am J Med Genet A. 132A: 283-7. PMID: 15690372
3. [Update on Bardet-Biedl syndrome].  |  Dollfus, H., et al. 2005. J Fr Ophtalmol. 28: 106-12. PMID: 15767906
4. Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort.  |  Hichri, H., et al. 2005. Eur J Hum Genet. 13: 607-16. PMID: 15770229
5. No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome.  |  Nakane, T. and Biesecker, LG. 2005. Am J Med Genet A. 138: 32-4. PMID: 16104012
6. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.  |  Nachury, MV., et al. 2007. Cell. 129: 1201-13. PMID: 17574030
7. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.  |  Young, JC., et al. 1998. J Biol Chem. 273: 18007-10. PMID: 9660753

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BBS8 Antibody (E-2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-BBS8 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BBS8 Antibody (E-2) Specifications

Alternate Product Name: BBS8

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 232-531

Epitope Target: BBS8

Epitope Species: human

Product Reactivity/Detection: BBS8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for BBS8 Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent