BAF53B Activators
BAF53 activators, in this context, refer to a collection of compounds that indirectly influence the activity of BAF53 by targeting the chromatin remodeling processes and gene expression regulation. BAF53, as a component of the SWI/SNF complex, plays a crucial role in the dynamic regulation of chromatin structure, which is pivotal for gene transcription. The compounds listed, such as Trichostatin A (TSA), 5-Azacytidine, SAHA (Vorinostat), and Valproic Acid, are primarily involved in modifying chromatin accessibility and structure through inhibition of histone deacetylases (HDACs) or altering DNA methylation patterns. These modifications can create a chromatin environment that influences the activity of chromatin remodeling complexes, including those containing BAF53.
The significance of compounds like Curcumin, Resveratrol, Sodium Butyrate, MS-275 (Entinostat), and Mithramycin A lies in their capacity to modulate gene expression and chromatin dynamics. By influencing the transcriptional landscape and chromatin accessibility, these agents can indirectly impact the functional dynamics of BAF53 in chromatin remodeling. Bromodomain inhibitors and specific compounds like JQ1 and Panobinostat further underscore the complexity of chromatin regulation. These inhibitors target the recognition and binding of acetylated histones, an essential aspect of chromatin modification and gene regulation, thereby potentially affecting the operational context in which BAF53 functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to affect various signaling pathways and may indirectly influence chromatin remodeling activities involving BAF53. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX-01294 inhibits the G9a histone methyltransferase, preventing histone H3 lysine 9 methylation. This change in the chromatin state can promote the accessibility and function of the BAF complex and BAF53B. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
This HDAC inhibitor could indirectly influence the chromatin remodeling activities of BAF53 by modifying histone acetylation. | ||||||
UNC 0642 | 1481677-78-4 | sc-397059 | 10 mg | $230.00 | 3 | |
UNC0642 is an inhibitor of the G9a/GLP histone methyltransferase. Reduced histone methylation fosters a chromatin structure that's more conducive for the BAF complex and BAF53B chromatin remodeling activity. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin specifically inhibits SUV39H1, a histone methyltransferase. In its absence, chromatin remains less compact, allowing the BAF complex containing BAF53B to function more effectively in remodeling activities. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, can modulate gene expression and might indirectly affect BAF53 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As an HDAC inhibitor, sodium butyrate can alter chromatin structure, potentially impacting BAF53 function. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is another G9a/GLP histone methyltransferase inhibitor. It paves the way for a chromatin arrangement that's more amendable to the actions of the BAF complex and the role BAF53B plays within it. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
binds to DNA and influences gene expression, potentially affecting BAF53's role in chromatin remodeling. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $148.00 $452.00 | 1 | |
GSK343 is an inhibitor of the EZH2 histone methyltransferase. By acting against this enzyme, it maintains chromatin in a state where the BAF53B-encompassing BAF complex can function more proficiently. | ||||||