ATPGD1 Inhibitors

ATPGD1 inhibitors, in the context of this table, are chemicals that have been selected based on their potential to indirectly modulate the function of ATPGD1. These compounds do not directly inhibit ATPGD1 but influence the enzyme's activity by modulating the levels of its substrates or by affecting signaling pathways that are related to the enzyme's physiological roles. For instance, ARL 67156 acts as an ectonucleotidase inhibitor and can indirectly increase the availability of extracellular nucleotides, including ATP, which could affect the enzymatic activity of ATPGD1 by saturating its substrate availability. Similarly, Suramin and PPADS are antagonists of P2 purinergic receptors, which are known to be involved in the regulation of extracellular ATP and ADP levels. By influencing purinergic signaling, these compounds may alter the function of ATPGD1 by changing the enzyme's local environment and substrate concentration.

Other compounds such as Sodium Azide and Probenecid act by different mechanisms but can also affect the activity of ATPGD1. Sodium Azide inhibits mitochondrial function, which can lead to an increase in extracellular nucleotide levels, while Probenecid inhibits organic anion transporters, potentially leading to elevated extracellular ATP, thereby affecting the activity of ATPGD1. The inhibitors listed work through various modes of action, including competitive inhibition, blockade of receptor-ligand interactions, and modulation of transporter functions, all of which converge on the purinergic system and the regulation of extracellular nucleotide concentrations. These changes in the extracellular milieu can influence ATPGD1 activity indirectly, as the enzyme's function is closely tied to the metabolic turnover of nucleotides outside the cell. The ability of these chemicals to influence ATPGD1 relies on the interconnected network of enzymes, transporters, and receptors that collectively regulate nucleotide levels and signaling in the extracellular space.