ATP8B4 Activators
ATP8B4 activators refer to a class of chemical compounds that target a specific cellular protein known as ATP8B4. ATP8B4 is an ATPase, which is an enzyme that catalyzes the hydrolysis of ATP (adenosine triphosphate) to ADP (adenosine diphosphate), releasing energy that the cell can use for various processes. ATPases like ATP8B4 play critical roles in maintaining the proper function of cellular membranes by regulating the transport of ions and molecules across the membrane. This, in turn, helps maintain the electrochemical gradients that are essential for the functioning of cells. Activators of ATP8B4 are designed to increase the activity of this enzyme, which can influence the dynamics of ion exchange and phospholipid flipping within cellular membranes.
The specific mechanism of action for ATP8B4 activators involves the binding of these molecules to the ATP8B4 enzyme, enhancing its intrinsic ATPase activity. This effect can lead to modifications in the phospholipid composition of membranes and may affect the membrane's fluidity and its interactions with other proteins embedded within it. These interactions are fundamental to the maintenance of cellular homeostasis and the modulation of signaling pathways. The precise biochemical pathways influenced by the activation of ATP8B4 and the cellular outcomes of such activation are areas of active research. The role of ATP8B4 in cellular physiology and its interaction with activators is complex, involving a network of regulatory mechanisms that ensure the proper balance of lipid transport and ion movement is maintained to support the diverse functions of the cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcimycin is a calcium ionophore that increases intracellular calcium levels, indirectly enhancing ATP8B4 activity as it may be required to restore calcium homeostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
As a PKC activator, PMA indirectly enhances ATP8B4 activity by altering the lipid environment of membranes, where ATP8B4 functions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By elevating cAMP, forskolin indirectly activates PKA, which can phosphorylate proteins and potentially enhance the activity of ATP8B4 by modifying its phosphorylation state. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil blocks voltage-dependent L-type calcium channels, which may lead to compensatory mechanisms that indirectly increase ATP8B4 activity to maintain calcium homeostasis. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that could indirectly enhance ATP8B4 activity through similar mechanisms as verapamil, affecting calcium homeostasis. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
As another calcium channel blocker, nitrendipine could indirectly necessitate enhanced ATP8B4 activity to compensate for disrupted calcium signaling. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine locks ryanodine receptors in an open state, increasing cytosolic calcium and possibly indirectly enhancing ATP8B4 activity to regulate calcium levels. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a membrane-permeable cAMP analogue that can activate PKA and potentially enhance ATP8B4 activity through similar mechanisms as cAMP. | ||||||