ATP8A2 Activators
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a known inhibitor of the Na⁺/K⁺-ATPase pump. By inhibiting this pump, ouabain increases intracellular Na⁺ levels, which can indirectly lead to the activation of ATP8A2 as the cell attempts to restore ionic balance through other ATPase activities. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Inhibition of these phosphatases can lead to increased phosphorylation of proteins within the cell, potentially enhancing the activity of ATP8A2 by promoting its phosphorylation state. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $37.00 $1132.00 $120.00 | 3 | |
4-Aminopyridine is a potassium channel blocker. It increases neuronal excitability and intracellular calcium levels, which could activate calcium-dependent ATPase pumps, including ATP8A2, to manage the altered ionic environment. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin, like ouabain, is a cardiac glycoside that inhibits the Na⁺/K⁺-ATPase pump. This inhibition can indirectly enhance the activity of ATP8A2 as part of the compensatory mechanisms of the cell. | ||||||
Veratridine | 71-62-5 | sc-201075B sc-201075 sc-201075C sc-201075A | 5 mg 10 mg 25 mg 50 mg | $80.00 $102.00 $197.00 $372.00 | 3 | |
Veratridine is a sodium channel activator. It disrupts the sodium equilibrium, potentially increasing the functional demand on ATP8A2 as the cell works to maintain ionic balance. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid is a chloride channel blocker, which could lead to increased intracellular chloride levels. This change in ionic concentration may activate chloride-sensitive ATPases, and ATP8A2 may be upregulated to handle the ionic imbalance. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the V-ATPases. Its inhibition of V-ATPases might lead to an increased role for P-type ATPases like ATP8A2 in maintaining proton gradients across membranes. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid is a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPases (SERCA). Inhibition of SERCA can lead to an increased demand on other ATPases, including ATP8A2, to manage calcium homeostasis. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a sodium-ionophore that disrupts Na+ homeostasis. The resulting ionic imbalance could necessitate an increased activity of ATP8A2 to help restore ionic equilibrium. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels, potentially enhancing the activity of calcium-dependent ATPases such as ATP8A2 to restore calcium balance. | ||||||