ATP5SL Inhibitors
ATP5SL inhibitors are a class of chemical compounds that target the ATP5SL protein, a lesser-known regulatory subunit associated with the ATP synthase complex, primarily found in the inner mitochondrial membrane. ATP synthase, also known as Complex V, is responsible for ATP production through oxidative phosphorylation, utilizing the proton gradient generated by the electron transport chain. While the main catalytic subunits of ATP synthase are well-characterized, ATP5SL is thought to play a supporting role in stabilizing the complex and regulating the interaction between its subunits. This regulation is essential for efficient energy conversion and ATP production, making ATP5SL a key player in maintaining cellular energy homeostasis.
Inhibitors of ATP5SL function by disrupting its regulatory role within the ATP synthase complex, potentially impairing the enzyme's ability to produce ATP efficiently. These inhibitors may bind to ATP5SL, causing structural changes that affect its interaction with other subunits, thereby compromising the assembly or functional stability of ATP synthase. Researchers often use methods such as molecular modeling, protein-ligand docking, and high-throughput screening to identify compounds that can selectively target ATP5SL without affecting the catalytic core of the ATP synthase complex. Structural studies, such as X-ray crystallography or cryo-electron microscopy, provide detailed insights into the binding sites and mechanisms of these inhibitors. By understanding how ATP5SL inhibitors alter mitochondrial energy production, researchers can gain valuable insights into the intricate regulation of ATP synthase and its broader impact on cellular metabolism and bioenergetics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. The activation of PKA can lead to phosphorylation events that enhance the functional activity of ATP5SL in ATP synthesis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can lead to an upregulation of cellular energy production pathways, indirectly enhancing the activity of ATP5SL by increasing the demand for ATP and thereby its synthesis. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin, though a known inhibitor of ATP synthase, at sub-inhibitory concentrations can cause a mild stress that potentially upregulates compensatory mechanisms, including the enhancement of ATP5SL activity to meet cellular energy demands. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $400.00 | 10 | |
Bongkrekic acid inhibits the opening of the mitochondrial permeability transition pore, thereby preserving mitochondrial membrane potential and indirectly supporting ATP5SL's role in ATP synthesis by maintaining an optimal proton gradient. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which through deacetylation of certain substrates can enhance mitochondrial biogenesis and, consequently, the activity of mitochondrial proteins like ATP5SL involved in ATP production. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN boosts NAD+ levels, which is a substrate for SIRT1. The activation of SIRT1 leads to improved mitochondrial function and could enhance ATP5SL activity involved in ATP synthesis. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is involved in the mitochondrial electron transport chain, which generates the proton gradient required for ATP synthesis. By optimizing this chain’s efficiency, Coenzyme Q10 can indirectly enhance the activity of ATP5SL. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid improves mitochondrial function and can indirectly augment ATP5SL activity by ensuring efficient energy metabolism and ATP production within mitochondria. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate activates PPARs, which can lead to upregulation of genes involved in mitochondrial function and fatty acid oxidation, indirectly enhancing the activity of ATP5SL by improving the substrate availability for ATP production. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $243.00 | ||
PQQ can stimulate mitochondrial biogenesis, thereby potentially increasing the number of ATP5SL molecules and enhancing the overall capacity for ATP synthesis in cells. | ||||||