ATP5C1 Inhibitors
ATP5C1 inhibitors act primarily through disruption of ATP synthesis and the electron transport chain, given that ATP5C1 is a part of the F-ATPase complex involved in ATP synthesis. Oligomycin A acts directly on the ATP synthase complex, inhibiting its function and thereby preventing ATP5C1 from contributing to ATP synthesis. Other compounds like 2,4-Dinitrophenol, FCCP, and Valinomycin disrupt the proton gradient across the mitochondrial membrane, a critical component for ATP synthesis. These agents uncouple oxidative phosphorylation, leading to decreased ATP production and hence ATP5C1 inhibition.
Other inhibitors affect ATP5C1 indirectly by inhibiting processes that lead to the generation of a proton gradient necessary for ATP synthesis. These include Azide, Rotenone, and Antimycin A, which inhibit different components of the electron transport chain. Iodoacetate, Malonate, and Sodium Arsenite inhibit enzymes involved in glycolysis and the citric acid cycle, decreasing the substrates available for the electron transport chain and thus reducing ATP synthesis. Atractyloside inhibits the adenine nucleotide translocase, reducing the availability of ADP, a necessary substrate for ATP synthesis. Tetrachloroauric acid has a more general inhibitory effect by binding to sulfhydryl groups of various enzymes, disrupting ATP production and thereby indirectly inhibiting ATP5C1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin A inhibits mitochondrial ATP synthase (F-ATPase), a complex ATP5C1 is a part of. By inhibiting ATP synthase, Oligomycin A prevents ATP production, leading to ATP5C1 being functionally inactive as it cannot contribute to ATP synthesis. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
2,4-Dinitrophenol uncouples mitochondrial oxidative phosphorylation by carrying protons across the mitochondrial membrane, bypassing ATP synthase. This action lowers ATP production and inhibits ATP5C1, which is part of the ATP synthase complex. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Azide is an inhibitor of cytochrome c oxidase in the electron transport chain. By inhibiting this chain, Azide prevents the proton gradient necessary for ATP synthase (including ATP5C1) to synthesize ATP, leading to an indirect inhibition of ATP5C1. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits the electron transport chain by blocking the transfer of electrons from iron-sulfur centers in Complex I to ubiquinone. This inhibits the generation of a proton gradient necessary for ATP synthesis, thereby inhibiting ATP5C1 function. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $250.00 | 1 | |
Iodoacetate inhibits the enzyme glyceraldehyde 3-phosphate dehydrogenase in glycolysis. This leads to decreased pyruvate and subsequently acetyl CoA, reducing the substrates available for the citric acid cycle and electron transport chain, thus indirectly inhibiting ATP5C1. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits the electron transport chain by blocking the transfer of electrons from cytochrome b to cytochrome c1. This inhibits the generation of a proton gradient necessary for ATP synthesis, thereby inhibiting ATP5C1 function. | ||||||
Tetrachloroauric Acid | 16903-35-8 | sc-473299 | 1 g | $342.00 | ||
Tetrachloroauric acid inhibits various enzymes by binding to sulfhydryl groups. This could disrupt several cellular processes, including ATP production, thereby indirectly inhibiting ATP5C1. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin is an ionophore that transports potassium ions across cell membranes, disrupting membrane potential. This can disrupt the proton gradient across the mitochondrial membrane, thus indirectly inhibiting ATP5C1 by preventing ATP synthesis. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP is a protonophore and uncoupler of oxidative phosphorylation in mitochondria. It dissipates the proton gradient across the mitochondrial inner membrane, preventing ATP synthesis and thus inhibiting ATP5C1. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium Arsenite inhibits pyruvate dehydrogenase, a key enzyme in the citric acid cycle. This leads to a decrease in the substrates for the electron transport chain, indirectly inhibiting ATP5C1. | ||||||