Atg4D Inhibitors
Atg4D Inhibitors consist of a diverse group of chemical compounds that interfere with the autophagic flux, thereby indirectly inhibiting the proteolytic activity of Atg4D on LC3-related proteins, which is essential for the autophagic process. For example, inhibitors of vacuolar H+-ATPase, such as Concanamycin A and Bafilomycin A1, prevent the acidification of lysosomes, a necessary step for the fusion of autophagosomes with lysosomes. Without proper acidification, the degradation of autophagic substrates is impaired, which in turn can affect the activity of Atg4D. Atg4D is crucial for preparing LC3-related proteins through delipidation, a process that allows the recycling of these proteins and the promotion of further autophagic events.
Other compounds, like Chloroquine and 3-Methyladenine, inhibit autophagy by different mechanisms. Chloroquine increases the pH of intracellular vesicles, which disrupts autophagosome maturation, while 3-Methyladenine inhibits class III PI3K, preventing the formation of autophagosomes at an early stage.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
A vacuolar H+-ATPase inhibitor that disrupts endosomal acidification. By increasing the pH within vesicles, it can inhibit the fusion between autophagosomes and lysosomes, thereby indirectly inhibiting Atg4D by preventing the substrate access necessary for its proteolytic cleavage activity on LC3-related proteins. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
This compound specifically inhibits V-ATPase, which is crucial for maintaining acidic pH in lysosomes. Inhibition of lysosomal acidification by Bafilomycin A1 can impede autophagosome-lysosome fusion, indirectly restricting Atg4D from accessing its substrates within autophagosomes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
A known autophagy inhibitor that raises the pH of acidic vesicles, impairing autophagosome maturation. Since Atg4D is implicated in autophagosome maturation, this alteration in pH can indirectly inhibit Atg4D's role in autophagy by preventing the processing of LC3-related proteins. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
A PI3K inhibitor that blocks the initiation of autophagy. By inhibiting the class III PI3K complex, it prevents the formation of autophagosomes, thus indirectly inhibiting Atg4D by reducing the number of autophagosomes available for the delipidation process. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
A selective autophagy inhibitor that promotes the degradation of Vps34 PI3K complex components. By destabilizing this complex, Spautin-1 indirectly inhibits Atg4D activity by decreasing the formation of autophagosomes, limiting Atg4D's role in processing LC3 proteins. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent PI3K inhibitor that also impairs autophagy initiation. Through its inhibition of PI3K, Wortmannin can reduce autophagosome formation, thereby indirectly decreasing Atg4D activity by reducing substrate availability. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A chemical inhibitor of PI3K, LY294002 hampers the formation of autophagosomes. By preventing the early stages of autophagy, it indirectly reduces Atg4D activity by limiting the number of autophagosomes for subsequent LC3 processing. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
A specific inhibitor of Vps34, which is part of the class III PI3K complex involved in autophagy initiation. By inhibiting Vps34, SAR405 can decrease autophagosome formation, which in turn indirectly inhibits Atg4D by reducing its substrate availability. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
An alkaloid that can disrupt microtubules and thus inhibit autophagosome transport to lysosomes. This disruption can lead to an accumulation of autophagosomes, potentially saturating Atg4D's capacity and thus indirectly inhibiting its functional activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A microtubule stabilizer that can inhibit the dynein motor complex, impairing autophagosome fusion with lysosomes. This inhibition can impede the late stages of autophagy, indirectly inhibiting Atg4D by preventing the turnover of LC3-related proteins. | ||||||