ASRGL1 Inhibitors
ASRGL1 inhibitors are a class of chemical compounds designed to target and modulate the activity of the enzyme known as L-asparaginase-like protein 1 (ASRGL1). ASRGL1 is a member of the L-asparaginase family of enzymes, which are involved in the regulation of asparagine and glutamine metabolism within cells. These enzymes catalyze the hydrolysis of asparagine or glutamine into aspartate or glutamate, respectively, thereby participating in various metabolic pathways. ASRGL1, in particular, plays a role in the regulation of asparagine levels within cells and is found in various tissues, including the liver and kidneys. Inhibitors of ASRGL1 are developed to interact with this enzyme, disrupting its catalytic activity and affecting cellular processes that rely on asparagine metabolism.
ASRGL1 inhibitors are typically designed as small molecules or compounds that can bind to ASRGL1, inhibiting its enzymatic activity. By interfering with the ability of ASRGL1 to hydrolyze asparagine, these inhibitors may lead to alterations in asparagine levels within the cell, affecting downstream metabolic pathways and cellular functions. Research into ASRGL1 inhibitors is essential for understanding the role of this enzyme in cellular metabolism and for exploring strategies to manipulate asparagine metabolism for various purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into DNA and RNA and can inhibit DNA methyltransferase, potentially reducing methylation and affecting gene expression, including ASRGL1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that can alter chromatin structure and potentially affect the transcription of various genes, including ASRGL1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Similar to Trichostatin A, it inhibits histone deacetylases, which could lead to changes in gene expression patterns and possibly downregulate ASRGL1 expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
A DNA methyltransferase inhibitor that can prevent DNA methylation, potentially impacting gene expression including that of ASRGL1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Another DNA methyltransferase inhibitor that can lead to hypomethylation of DNA and possibly affect the expression of ASRGL1. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
An HDAC inhibitor that can change gene expression patterns and might influence ASRGL1 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A short-chain fatty acid and HDAC inhibitor that can affect gene expression and may potentially downregulate ASRGL1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Used in research to inhibit acetaldehyde dehydrogenase, and can indirectly affect various signaling pathways, potentially impacting ASRGL1 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
A compound that binds DNA and can inhibit RNA synthesis, potentially decreasing the expression of certain genes such as ASRGL1. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
A compound that can intercalate into DNA, inhibiting RNA polymerase and thus potentially downregulating gene expression, including that of ASRGL1. | ||||||