Disulfiram CAS: 97-77-8
MF: C10H20N2S4
MW: 296.54
An ALDH and tumor cell growth inhibitor.

Disulfiram (CAS 97-77-8)

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別名: Tetraethylthiuram disulfide
アプリケーション: Disulfiram is an ALDH and tumor cell growth inhibitor
CAS 番号: 97-77-8
Purity: ≥97%
Molecular Weight: 296.54
Molecular Formula: C10H20N2S4
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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* Refer to Certificate of Analysis for lot specific data (including water content).

Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase.


参考文献

1. Brady, J.F., et al. 1991. Toxicol. Appl. Pharmacol. 108: 366-373. PMID: 1850173
2. Schroeder, J.P., et al. 2010. Neuropsychopharmacology. 35: 2440-2449. PMID: 20736996
3. Lin, J., et al. 2010. Prostate. [Epub ahead of print]. PMID: 20809552
4. Wang, F., et al. 2011. Cancer Lett. 300: 87-95. PMID: 21035945

Physical State :
Solid
Solubility :
Soluble in water (4 mg/l at 25° C), acohol (38.2 mg/ml), ether (71.4 mg/ml), chloroform, and acetonitrile.
保存方法 :
Store at room temperature
Melting Point :
69-71° C (lit.)
Boiling Point :
117.2° C at 17 mmHg
Density :
1.3 g/cm3
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
MCF7: IC50 = 0.1 µM (human); T47D: IC50 = 0.17 µM (human); MDA-MB-231: IC50 = 0.32 µM (human); Adenosine A3-R: IC50 = 0.36 µM (human); D3DR: IC50 = 1.08 µM (human)
Ki Data :
Adenosine A3-R: Ki= 0.2 µM (human); D3DR: Ki= 0.37 µM (human); CKR-2B: Ki= 0.95 µM (human); D1DR: Ki= 1.08 µM (human); D4DR: Ki= 1.11 µM (human)
pK Values :
pKb: 0.86 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
JO1225000
PubChem CID :
Merck Index :
14: 3364
MDL Number :
MFCD00009048
EC Number :
202-607-8
Beilstein Registry :
1712560
SMILES :
CCN(CC)C(=S)SSC(=S)N(CC)CC

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Disulfiram (CAS 97-77-8)  参考文献

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引用 1 to 3 of 3 合計

PMID: # 26577527  Mali, VR. et al. 2016. Cell. Signal. 28: 1-6.

PMID: # 33009395  Nat Commun. 4958.

PMID: # 27203215  Oncotarget. 82200-82212.

引用 1 to 3 of 3 合計
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