ASB-17 Inhibitors
ASB-17 inhibitors are a class of chemical compounds that specifically inhibit the activity of ASB-17, a protein belonging to the ankyrin repeat and SOCS box-containing family (ASB). ASB proteins are part of a larger protein family that regulates the degradation of other proteins by facilitating their ubiquitination. ASB-17, in particular, is involved in cellular processes linked to protein degradation pathways, contributing to maintaining cellular homeostasis. The inhibitors of ASB-17 typically function by interfering with its interaction with specific substrates or components of the ubiquitination machinery, thereby modifying the degradation process of certain proteins. These inhibitors are often studied to better understand how ASB-17 functions within the broader context of proteostasis and intracellular signaling pathways.
Research into ASB-17 inhibitors also highlights their importance in protein-protein interaction modulation and the regulation of cell cycle-related processes. By preventing the normal function of ASB-17, these inhibitors can be used as chemical tools to dissect the specific pathways in which this protein plays a role, such as in the turnover of target proteins that are critical to maintaining balance within various cellular compartments. Due to their capacity to alter protein degradation dynamics, ASB-17 inhibitors are valuable in studies involving the ubiquitin-proteasome system, where precise control of protein degradation is essential for normal cellular operation. This class of inhibitors continues to be a point of interest in biochemical research, primarily for understanding the molecular mechanics of protein regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA at the transcription initiation complex, which could downregulate ASB17 gene expression by obstructing RNA polymerase movement and mRNA synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide disrupts eukaryotic protein elongation, which would lead to a decrease in ASB17 protein levels by halting the addition of amino acids to the polypeptide chain during translation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin forms a complex with FKBP12 that specifically inhibits mTORC1, potentially leading to a reduction in cap-dependent translation, thereby decreasing ASB17 protein synthesis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into the DNA double helix, which could result in decreased transcription of the ASB17 gene by obstructing the access of essential transcriptional enzymes and machinery. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin binds with high affinity to RNA polymerase II, which could lead to a significant decrease in the transcription of the ASB17 gene by inhibiting the polymerase's ability to synthesize mRNA. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit the transcription of multiple genes, potentially reducing ASB17 expression by preventing the initiation or elongation phases of RNA polymerase II-mediated mRNA transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to GC-rich sequences in promoter regions, which could repress ASB17 gene expression by preventing transcription factor binding and initiation complex formation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine's DNA intercalation properties could repress ASB17 gene expression by inhibiting the replication and transcription of DNA, disrupting the synthesis of mRNA necessary for protein production. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil metabolites misincorporate into RNA, which could inhibit the proper processing and function of ASB17 mRNA, potentially leading to nonfunctional or degraded mRNA transcripts. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB selectively inhibits RNA polymerase II's transcriptional elongation, which could lead to a specific decrease in ASB17 mRNA levels, reducing the amount of mRNA available for translation into protein. | ||||||