Aryl Hydrocarbon Receptor Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
D,L-Sulforaphane is a potent modulator of the Aryl Hydrocarbon Receptor (AhR), characterized by its electrophilic nature that promotes covalent interactions with cysteine residues in AhR. This compound's unique structure enables it to induce conformational changes in the receptor, enhancing its transcriptional activity. Additionally, D,L-Sulforaphane activates various signaling cascades, influencing cellular responses and gene regulation through distinct post-translational modifications. | ||||||
CH 223191 | 301326-22-7 | sc-293991 sc-293991A | 10 mg 50 mg | $194.00 $831.00 | 2 | |
CH 223191 is a selective antagonist of the Aryl Hydrocarbon Receptor (AhR), exhibiting unique binding dynamics that disrupt the receptor's activation by endogenous ligands. Its structural features allow for specific interactions with the AhR ligand-binding domain, inhibiting downstream signaling pathways. This compound's ability to modulate AhR activity influences various biological processes, including xenobiotic metabolism and immune responses, through distinct regulatory mechanisms. | ||||||
PDM 2 | 688348-25-6 | sc-205428 sc-205428A | 10 mg 50 mg | $53.00 $315.00 | ||
PDM 2 acts as a potent modulator of the Aryl Hydrocarbon Receptor (AhR), characterized by its ability to stabilize the receptor in an inactive conformation. This compound engages in specific hydrogen bonding and hydrophobic interactions within the AhR binding pocket, effectively preventing the receptor from initiating transcriptional activity. Its unique kinetic profile allows for rapid dissociation from the receptor, enabling fine-tuned regulation of AhR-mediated pathways, impacting cellular responses to environmental stimuli. | ||||||
α-Naphthoflavone | 604-59-1 | sc-257037 sc-257037A sc-257037B sc-257037C | 1 g 5 g 25 g 100 g | $33.00 $45.00 $153.00 $490.00 | 3 | |
α-Naphthoflavone is a selective antagonist of the Aryl Hydrocarbon Receptor (AhR), exhibiting unique binding dynamics that disrupt the receptor's interaction with its ligands. It forms distinct π-π stacking interactions and hydrophobic contacts, altering the conformational landscape of AhR. This compound influences downstream signaling pathways by modulating the receptor's transcriptional activity, showcasing a nuanced ability to affect gene expression in response to xenobiotic exposure. | ||||||
6,2',4'-Trimethoxyflavone | 720675-90-1 | sc-291423 sc-291423A sc-291423B sc-291423C | 10 mg 50 mg 500 mg 1 g | $70.00 $270.00 $1503.00 $2000.00 | ||
6,2',4'-Trimethoxyflavone acts as a modulator of the Aryl Hydrocarbon Receptor (AhR), engaging in specific hydrogen bonding and hydrophobic interactions that stabilize its binding. This compound alters the receptor's structural conformation, impacting its ability to dimerize with ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator). By influencing the recruitment of co-regulators, it fine-tunes the transcriptional response to environmental stimuli, showcasing its role in cellular signaling pathways. | ||||||
(S)-Sulforaphane | 155320-20-0 | sc-208377 sc-208377A | 10 mg 100 mg | $638.00 $3188.00 | ||
(S)-Sulforaphane is a potent ligand for the Aryl Hydrocarbon Receptor (AhR), exhibiting unique interactions that enhance receptor activation. Its structure allows for effective π-π stacking and van der Waals forces, promoting a stable binding conformation. This compound influences downstream signaling by modulating the expression of genes involved in detoxification and antioxidant responses, thereby playing a critical role in cellular defense mechanisms against environmental stressors. | ||||||
1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene | 688348-37-0 | sc-220545 sc-220545A | 10 mg 25 mg | $22.00 $51.00 | ||
1,3-Dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene acts as a selective modulator of the Aryl Hydrocarbon Receptor (AhR), showcasing distinct molecular interactions that facilitate receptor binding. Its unique chlorinated aromatic structure enables strong hydrophobic interactions and potential hydrogen bonding, influencing AhR-mediated transcriptional activity. This compound can alter gene expression patterns related to xenobiotic metabolism, impacting cellular responses to environmental pollutants. | ||||||